Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
Department of Radiation Oncology, University of Washington, Seattle, WA.
Semin Radiat Oncol. 2018 Jun;28(3):201-206. doi: 10.1016/j.semradonc.2018.02.005.
The International Commission on Radiation Units and Measurements (ICRU) volumes are standardized volume definitions used in radiation oncology practice that have evolved over time to account for advancements in technology and radiation planning. The current definitions have strengths but also practical limitations. The main limitation is related to the process of accounting for tumor motion during treatment. As radiotherapeutic techniques become more precise, motion interplay effects and anatomical changes during treatment must be taken into account to ensure accurate and safe delivery of treatment. Adaptive replanning can help to mitigate the effect of these uncertainties and widen the therapeutic ratio by maximizing dose to the tumor and protecting critical normal structures. As adaptive replanning becomes more common, standardization of how adaptive therapy is implemented and reported will become necessary.
国际辐射单位和测量委员会（ICRU）体积是放射肿瘤学实践中使用的标准化体积定义，随着时间的推移，这些定义不断发展，以适应技术和放射计划的进步。当前的定义有其优势，但也有实际的局限性。主要的限制与治疗过程中肿瘤运动的计算有关。随着放射治疗技术变得更加精确，在治疗过程中必须考虑运动相互作用效应和解剖结构的变化，以确保治疗的准确和安全。自适应计划可以帮助减轻这些不确定性的影响，并通过最大限度地提高肿瘤剂量和保护关键的正常结构来扩大治疗比率。随着自适应计划变得越来越普遍，有必要对如何实施和报告自适应治疗进行标准化。
