Gelmetti Alessandra, Greppi Noemi, Guez Sophie, Grassi Francesca, Rebulla Paolo, Tadini Gianluca
Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, University of Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Blood Transfusion Service, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Transfus Apher Sci. 2018 Jun;57(3):370-373. doi: 10.1016/j.transci.2018.05.021. Epub 2018 May 10.
The management of patients affected by epidemolysis bullosa requires an integrated approach involving different specialties. A cornerstone of clinical management is the prevention and treatment of mechanobullous ulcerations of the patient's skin, which significantly impact the quality of life and can be the cause of septic and neoplatic complications. This article describes the preliminary clinical evaluation of the use of allogeneic cord blood platelet gel, a novel blood component obtained from umbilical cord blood of healthy, term neonates, for the treatment of skin ulcers in patients with dystrophic epidermolysis bullosa. The promising clinical results obtained in this small patient group support the development of larger controlled clinical trials to compare the efficacy of platelet gel obtained from cord blood versus traditional platelet gel prepared from adult blood donors and versus current standard approaches of wound care in these patients.
大疱性表皮松解症患者的管理需要多专科参与的综合治疗方法。临床管理的一个基石是预防和治疗患者皮肤的机械性大疱性溃疡，这些溃疡会显著影响生活质量，并可能导致败血症和肿瘤并发症。本文描述了使用同种异体脐血血小板凝胶（一种从健康足月新生儿脐带血中获得的新型血液成分）治疗营养不良性大疱性表皮松解症患者皮肤溃疡的初步临床评估。在这个小患者群体中获得的有前景的临床结果支持开展更大规模的对照临床试验，以比较脐血来源的血小板凝胶与成年献血者制备的传统血小板凝胶以及这些患者当前伤口护理标准方法的疗效。
