Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Department of Biotechnology, Faculty of Advanced Science & Technology, Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Wound Repair Regen. 2021 Jan;29(1):134-143. doi: 10.1111/wrr.12865. Epub 2020 Oct 19.
Epidermolysis bullosa (EB) is a rare genetic disorder characterized by the formation of blisters and wounds in skin and mucous membranes; it is classified into four types and has various methods of treatment. Management of previous wounds and prevention of formation of new lesions are the most important strategies in the course of therapy to improve patient's quality of life; lack of wound management can lead to further complications such as infection. The current study investigated the therapeutic effects of allogeneic platelet gel (prepared from umbilical cord blood) in a group of children diagnosed with dystrophic epidermolysis bullosa (DEB) eligible for surgical correction of pseudosyndactyly in the hand. The post-surgical clinical outcome in this group was compared with the clinical outcomes of DEB patients receiving the standard treatment (paraffin gauze wound dressing and topical antibiotics) after corrective surgery. The current study results showed an increase in the rate of recovery and promotion of tissue granulation, complete wound healing, and a decrease in pain level and treatment period. The application of cord blood platelet gel topical dressing was not a conventional method of treatment in patients with DEB wounds and blisters. However, the current study results demonstrated that this gel dressing could effectively accelerate epithelialization and healing of the wounds and decrease patients' pain and post-surgical recovery period, which altogether leads to improvements in patients' overall quality of life.
大疱性表皮松解症（EB）是一种罕见的遗传性疾病，其特征是皮肤和黏膜形成水疱和伤口；它分为四型，有多种治疗方法。治疗过程中最重要的策略是管理先前的伤口并预防新损伤的形成，以提高患者的生活质量；伤口管理不善可能导致进一步的并发症，如感染。本研究调查了同种异体血小板凝胶（由脐带血制备）在一组适合手部假性并指畸形矫正手术的营养不良性大疱性表皮松解症（DEB）儿童中的治疗效果。该组患者在手术后的临床结果与接受标准治疗（石蜡纱布伤口敷料和局部抗生素）后的 DEB 患者的临床结果进行了比较。本研究结果表明，该治疗方法可提高愈合率和促进组织肉芽形成，实现完全伤口愈合，并降低疼痛水平和治疗周期。脐带血血小板凝胶局部敷料的应用并不是 DEB 患者伤口和水疱的常规治疗方法。然而，本研究结果表明，这种凝胶敷料可有效加速上皮化和伤口愈合，并减轻患者的疼痛和术后恢复时间，从而整体提高患者的生活质量。
