逆境暴露大脑的表观遗传学景观。
Epigenetic Landscapes of the Adversity-Exposed Brain.
机构信息
University of Delaware, Newark, DE, United States.
University of Delaware, Newark, DE, United States.
出版信息
Prog Mol Biol Transl Sci. 2018;157:1-19. doi: 10.1016/bs.pmbts.2017.11.025. Epub 2018 Feb 24.
Abstract
It is understood that adversity during development has the power to alter behavioral trajectories, and the role of the epigenome in that relationship is currently under intense investigation. Several studies in both nonhuman animals and humans have established a link between early adversity and epigenetic regulation of genes heavily implicated in the stress response, plasticity and cognition, and psychiatric disorders such as depression and anxiety. Thus the relatively recent surge of studies centering on the epigenetic outcomes of stress has great potential to inform treatments and interventions for psychiatric disorder precipitated by early adversity. Here we review what we know and what we do not know, and suggest approaches to help further elucidate the relationship between early adversity, epigenetics, and behavior.
摘要
据了解，发育过程中的逆境有能力改变行为轨迹，而表观基因组在这种关系中的作用目前正在受到深入研究。在非人类动物和人类中进行的几项研究已经建立了早期逆境与应激反应、可塑性和认知以及抑郁症和焦虑症等精神障碍中高度涉及的基因的表观遗传调控之间的联系。因此，目前集中研究应激的表观遗传后果有可能为早期逆境引发的精神障碍的治疗和干预提供信息。在这里，我们回顾了我们所知道的和我们所不知道的，并提出了一些方法来帮助进一步阐明早期逆境、表观遗传学和行为之间的关系。
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