Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
J Antibiot (Tokyo). 2018 Aug;71(8):688-701. doi: 10.1038/s41429-018-0029-z. Epub 2018 Jun 22.
Staurosporine, together with such examples as penicillin, aspirin, ivermectin and sildenafil, exemplifies the role that serendipity has in drug discovery and why 'finding things without actually searching for them' retains a prominent role in drug discovery. Hitherto not clinically useful, due to its potency and promiscuity, new delivery technology is opening up new horizons for what was previously just the parent compound of innovative, highly-successful anti-cancer agents.
作为一个例子，依托泊苷与青霉素、阿司匹林、伊维菌素和西地那非等药物一样，体现了偶然在药物发现中的作用，以及为什么“在没有实际搜索的情况下找到东西”在药物发现中仍然占有突出地位。由于其效力和混杂性，迄今为止尚未在临床上使用，但新的给药技术为以前仅仅是创新、高度成功的抗癌药物母体化合物的药物开辟了新的前景。
