Department of Pathology and Cell Biology, University of Montreal, Montreal, QC, Canada H1T 2M4; Research Center, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada H1T 2M4.
Research Center, Maisonneuve-Rosemont Hospital, Montreal, QC, Canada H1T 2M4.
Eur J Pharmacol. 2018 Aug 15;833:339-348. doi: 10.1016/j.ejphar.2018.06.025. Epub 2018 Jun 20.
The formyl peptide receptors (FPRs) are G protein coupled receptors that recognize a broad range of structurally distinct pathogen and danger-associated molecular patterns and mediate host defense to infection and tissue injury. It became evident that the cellular distribution and biological functions of FPRs extend beyond myeloid cells and governing their activation and trafficking. In recent years, significant progress has been made to position FPRs at check points that control the resolution of inflammation, tissue repair and return to homeostasis. Accumulating data indicate a role for FPRs in an ever-increasing range of human diseases, including atherosclerosis, chronic obstructive pulmonary disease, asthma, autoimmune diseases and cancer, in which dysregulated or defective resolution are increasingly recognized as critical component of the pathogenesis. This review summarizes recent advances on how FPRs recognize distinct ligands and integrate opposing cues to govern various responses and will discuss how this knowledge could be harnessed for developing novel therapeutic strategies to counter inflammation that underlies many human diseases.
甲酰肽受体（FPRs）是 G 蛋白偶联受体，能够识别广泛的结构不同的病原体和危险相关的分子模式，并介导宿主对感染和组织损伤的防御。很明显，FPRs 的细胞分布和生物学功能超出了髓样细胞的范围，并控制着它们的激活和运输。近年来，在控制炎症、组织修复和恢复体内平衡的各个检查点定位 FPRs 方面取得了重大进展。越来越多的数据表明，FPRs 在包括动脉粥样硬化、慢性阻塞性肺疾病、哮喘、自身免疫性疾病和癌症在内的越来越多的人类疾病中发挥作用，其中失调或缺陷的分辨率越来越被认为是发病机制的关键组成部分。这篇综述总结了 FPRs 识别不同配体和整合相反信号的最新进展，以控制各种反应，并将讨论如何利用这些知识开发新的治疗策略来对抗炎症，炎症是许多人类疾病的基础。
