Infection Biology, Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Infection Biology, Interfaculty Institute for Microbiology and Infection Medicine Tübingen (IMIT), University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.
Trends Immunol. 2018 Oct;39(10):815-829. doi: 10.1016/j.it.2018.08.005. Epub 2018 Sep 5.
Formyl-peptide receptors (FPRs) recognize bacterial and mitochondrial formylated peptides as well as endogenous non-formylated peptides and even lipids. FPRs are expressed on various host cell types but most strongly on neutrophils and macrophages. After the discovery of FPRs on leukocytes, it was assumed that these receptors predominantly govern a proinflammatory response resulting in chemotaxis, degranulation, and oxidative burst during infection. However, it is clear that the activation of FPRs has more complex consequences and can also promote the resolution of inflammation. Recent studies have highlighted associations between FPR function and inflammatory conditions, including inflammatory disorders, cancer, and infection. In this review we discuss these recent findings.
甲酰肽受体（FPRs）识别细菌和线粒体甲酰化肽以及内源性非甲酰化肽，甚至脂质。FPRs 表达于各种宿主细胞类型，但在中性粒细胞和巨噬细胞中表达最强。在白细胞上发现 FPRs 后，人们认为这些受体主要控制炎症反应，导致感染过程中的趋化性、脱颗粒和氧化爆发。然而，很明显，FPR 的激活会产生更复杂的后果，也可以促进炎症的消退。最近的研究强调了 FPR 功能与炎症性疾病、癌症和感染之间的关联。在这篇综述中，我们讨论了这些最新发现。
