Provoost A P, Van Aken M
J Nucl Med. 1985 Sep;26(9):1063-7.
The renal handling of technetium-99m dimercaptosuccinic acid ([99mTc]DMSA) was studied in rats before and after treatment with Na-maleate (2 mmol/kg i.v.). In the control period, when measured 2 hr after the intravenous injection of [99mTc]DMSA, 39.9% of the injected dose was in the kidneys and 14.6% was in the bladder. After Na-maleate treatment, only 6.4% of the injected dose of [99mTc]DMSA was retained in the kidneys while 37.9% was found in the bladder. Subsequent studies revealed that Na-maleate produced a fall in the glomerular filtration rate, the effective renal plasma flow, and a generalized proximal tubular dysfunction. The latter was characterized by polyuria and an increased excretion of glucose, protein, albumin, calcium, and inorganic phosphate. It was concluded that proximal tubular dysfunction markedly alters the renal handling of [99mTc]DMSA. Whether this augmented urinary excretion is due to an inhibition of reabsorption or an enhanced cellular efflux of [99mTc]DMSA remains to be answered.
在大鼠静脉注射马来酸钠（2 mmol/kg）前后，研究了其对锝-99m二巯基丁二酸（[99mTc]DMSA）的肾脏处理情况。在对照期，静脉注射[99mTc]DMSA 2小时后测量发现，注入剂量的39.9%在肾脏中，14.6%在膀胱中。马来酸钠处理后，[99mTc]DMSA注入剂量中仅6.4%保留在肾脏中，而37.9%在膀胱中被发现。随后的研究表明，马来酸钠导致肾小球滤过率、有效肾血浆流量下降，并出现广泛性近端肾小管功能障碍。后者的特征为多尿以及葡萄糖、蛋白质、白蛋白、钙和无机磷酸盐排泄增加。得出的结论是，近端肾小管功能障碍显著改变了[99mTc]DMSA的肾脏处理情况。这种尿排泄增加是由于[99mTc]DMSA重吸收受抑制还是细胞外排增强，仍有待解答。
