Sugarbaker Paul H
Program in Peritoneal Surface Oncology, Center for Gastrointestinal Malignancies, MedStar Washington Hospital Center, 106 Irving Street, Northwest, Suite 3900, Washington, DC 20010, USA.
Surg Oncol Clin N Am. 2018 Jul;27(3):413-424. doi: 10.1016/j.soc.2018.02.001.
The treatments for peritoneal metastases have evolved over 30 years. Now the concepts that guided clinicians are being tested in clinical trials to optimize standardized treatment regimens. The essential features of a successful management plan are cytoreductive surgery combined with cancer chemotherapy in a large volume of intraperitoneal fluid administered into the peritoneal space. The cytotoxicity of the cancer chemotherapy is maximized by moderate hyperthermia. The patients must be carefully selected using well-defined prognostic indicators. The efforts to date are multinational with centers of excellence located throughout the world.
腹膜转移瘤的治疗方法在过去30年中不断发展。如今，指导临床医生的理念正在临床试验中接受检验，以优化标准化治疗方案。成功的管理计划的基本特征是细胞减灭术联合癌症化疗，并向腹腔内注入大量腹腔积液。适度热疗可使癌症化疗的细胞毒性最大化。必须使用明确的预后指标仔细挑选患者。迄今为止，这项工作是跨国性的，全球各地都有卓越中心参与。
