朝圣期间肺炎链球菌所致临床感染负担：系统评价。
Burden of clinical infections due to S. pneumoniae during Hajj: A systematic review.
机构信息
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (NCIRS), Kids Research Institute at The Children's Hospital at Westmead, Westmead, NSW 2145, Australia; School of Public Health, The University of Sydney, Sydney, New South Wales, Australia; Saudi Food and Drug Authority, Riyadh, Saudi Arabia.
National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (NCIRS), Kids Research Institute at The Children's Hospital at Westmead, Westmead, NSW 2145, Australia; The Discipline of Child and Adolescent Health, The Children's Hospital at Westmead Clinical School, The University of Sydney Medical School, Australia; Faculty of Medicine, University of Tripoli, Ain Zara, Tripoli, Libya.
出版信息
Vaccine. 2018 Jul 16;36(30):4440-4446. doi: 10.1016/j.vaccine.2018.04.031. Epub 2018 Jun 20.
The burden of pneumococcal disease at Hajj has not been precisely evaluated through a systematic review. To this end we have conducted a systematic review on the burden of clinical infections due to Streptococcus pneumoniae among Hajj pilgrims. Major electronic databases including OVID Medline, Web of Science, OVID Embase, Social Sciences Citation Index, Google Scholar and relevant websites (e.g., online Saudi Epidemiology Bulletin) were searched by using MeSH terms and text words containing but not limited to 'Hajj', pneumonia and S. pneumoniae. This was buttressed by hand searching of reference lists of identified studies. Of 21 full text papers reviewed, nine articles were included in this review. Seven studies reported the burden of pneumococcal pneumonia and the other two reported the burden of invasive pneumococcal diseases including meningitis and sepsis. The proportion of pneumonia that was pneumococcal ranged from 1% to 54% of bacteriologically confirmed pneumonias. The pneumococcus accounted for 2/3rd of bacteriologically diagnosed meningitis cases, and 1/3rd of confirmed cases of sepsis. Case fatality rate of pneumococcal pneumonia was recorded in only two studies: 33.3% and 50%. Only one study provided data on antimicrobial susceptibility of S. pneumoniae isolates, reporting 33.3% to be penicillin resistant. None of the included studies provided data on serotype distribution of S. pneumoniae. This systematic review highlights the significance of pneumococcal disease during Hajj, and demonstrates paucity of data on its burden particularly on disease-causing serotype.
朝觐期间肺炎球菌病的负担尚未通过系统评价进行准确评估。为此，我们对朝觐朝圣者中由肺炎链球菌引起的临床感染负担进行了系统评价。主要的电子数据库，包括 OVID Medline、Web of Science、OVID Embase、社会科学引文索引、Google Scholar 和相关网站（例如，在线沙特流行病学公报），使用 MeSH 术语和包含但不限于“朝觐”、肺炎和 S. pneumoniae 的文本词进行了搜索。这通过对已确定研究的参考文献列表进行手动搜索得到了补充。在审查的 21 篇全文论文中，有 9 篇文章被纳入本综述。有 7 项研究报告了肺炎球菌性肺炎的负担，另外两项研究报告了侵袭性肺炎球菌病的负担，包括脑膜炎和败血症。经细菌学证实的肺炎中，肺炎球菌性肺炎的比例为 1%至 54%。肺炎球菌占细菌学诊断为脑膜炎病例的 2/3，占败血症确诊病例的 1/3。只有两项研究记录了肺炎球菌性肺炎的病死率：33.3%和 50%。只有一项研究提供了肺炎链球菌分离株的抗菌药物敏感性数据，报告称 33.3%对青霉素耐药。纳入的研究均未提供肺炎链球菌血清型分布的数据。这项系统评价强调了朝觐期间肺炎球菌病的重要性，并表明其负担的数据，特别是关于致病血清型的数据，非常有限。
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