IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
University of Cagliari, DICAAR, Italy.
Exp Eye Res. 2018 Oct;175:159-165. doi: 10.1016/j.exer.2018.06.022. Epub 2018 Jun 21.
Purpose of present study is to evaluate whether the Pre-Macular Bursa (PMB) modifies Wall Shear Stress (WSS) at the retinal surface during saccadic movements. We created a mathematical model consisting of 25,000 grid cells and simulated a horizontal saccade spanning 50° in 0.17s, both in absence and in presence of the PMB. Wall Shear Stress SS was computed throughout the retinal surface and the posterior pole was divided into 3 Zones comprising 400 nodes each: Zone 1 (radius 3.5 mm; 0°-17°) corresponding to the PMB area; Zone 2 (concentric annular area 5 mm in radius; 22°) and Zone 3 (concentric annular area 5.5 mm; 28°). The PMB reduced WSS significantly at the macula and increased it in the immediate surroundings. Average WSS in Zone 1 was 1.53 ± 1.01 (max 4.23 Pa) with PMB Vs 6.94 ± 9.23 (max 35.83 Pa) without. Zone 2 WSS was 9.39 ± 10.33 (max 48.36 Pa) with PMB Vs 6.95 ± 9.40 (max 38.60 Pa) without Zone 3 WSS was 8.41 ± 10.03 (max 43.16 Pa) with PMB Vs 6.88 ± 9.42 (max 39.43 Pa) without (p < 0.001 in all cases). The PMB significantly reduces WSS over the retinal surface underlying the bursa region; conversely, WSS slightly increases it in the immediate neighboring areas.
本研究旨在评估黄斑前囊（PMB）是否会改变眼跳过程中视网膜表面的壁面切应力（WSS）。我们创建了一个由 25000 个网格单元组成的数学模型，并模拟了一个跨越 50°的水平眼跳，时间为 0.17s，同时考虑了和不考虑 PMB 的情况。我们计算了整个视网膜表面的壁面切应力 SS，并将后极分为 3 个区，每个区包含 400 个节点：区 1（半径 3.5mm；0°-17°）对应于 PMB 区域；区 2（半径 5mm 的同心环形区域；22°）和区 3（半径 5.5mm 的同心环形区域；28°）。PMB 显著降低了黄斑区的 WSS，并增加了其周围的 WSS。PMB 存在时，区 1 的平均 WSS 为 1.53±1.01（最大 4.23Pa），而 PMB 不存在时为 6.94±9.23（最大 35.83Pa）。PMB 存在时，区 2 的 WSS 为 9.39±10.33（最大 48.36Pa），而 PMB 不存在时为 6.95±9.40（最大 38.60Pa）。PMB 存在时，区 3 的 WSS 为 8.41±10.03（最大 43.16Pa），而 PMB 不存在时为 6.88±9.42（最大 39.43Pa）。所有情况下 p 值均<0.001。PMB 显著降低了囊区下方视网膜表面的 WSS；相反，它略微增加了其周围区域的 WSS。
