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Regulatory T cells as a biomarker for response to adalimumab in rheumatoid arthritis.

作者信息

Nguyen Dao X, Cotton Alice, Attipoe Laura, Ciurtin Coziana, Doré Caroline J, Ehrenstein Michael R

机构信息

Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom.

Comprehensive Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, London, United Kingdom.

出版信息

J Allergy Clin Immunol. 2018 Sep;142(3):978-980.e9. doi: 10.1016/j.jaci.2018.04.026. Epub 2018 Jun 20.

DOI:10.1016/j.jaci.2018.04.026
PMID:29935955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6127034/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/aaa8e1e2562e/fx4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/fa917a90319b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/285ec378d8ac/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/eb094a2375ec/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/aee02c7e46ed/fx3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/aaa8e1e2562e/fx4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/fa917a90319b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/285ec378d8ac/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/eb094a2375ec/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/aee02c7e46ed/fx3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a87/6127034/aaa8e1e2562e/fx4.jpg

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Regulatory T cells as a biomarker for response to adalimumab in rheumatoid arthritis.调节性T细胞作为类风湿关节炎中对阿达木单抗反应的生物标志物。
J Allergy Clin Immunol. 2018 Sep;142(3):978-980.e9. doi: 10.1016/j.jaci.2018.04.026. Epub 2018 Jun 20.
2
Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy.在对抗肿瘤坏死因子抗体治疗有反应的类风湿性关节炎患者中，Th17细胞通过白细胞介素-6的抑制作用受到调节性T细胞的抑制。
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Nat Rev Rheumatol. 2025 Jan;21(1):9-21. doi: 10.1038/s41584-024-01190-w. Epub 2024 Dec 9.
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本文引用的文献

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Precision Medicine in Rheumatoid Arthritis.类风湿关节炎中的精准医学
Rheum Dis Clin North Am. 2017 Aug;43(3):377-387. doi: 10.1016/j.rdc.2017.04.008.
2
Anti-TNF drives regulatory T cell expansion by paradoxically promoting membrane TNF-TNF-RII binding in rheumatoid arthritis.在类风湿性关节炎中，抗TNF通过反常地促进膜TNF与TNF-RII的结合来驱动调节性T细胞的扩增。
J Exp Med. 2016 Jun 27;213(7):1241-53. doi: 10.1084/jem.20151255. Epub 2016 Jun 6.
3
Methotrexate Restores Regulatory T Cell Function Through Demethylation of the FoxP3 Upstream Enhancer in Patients With Rheumatoid Arthritis.
预测类风湿关节炎中 DMARDs 疗效和不良反应的生物标志物。
Front Immunol. 2022 Mar 28;13:865267. doi: 10.3389/fimmu.2022.865267. eCollection 2022.
4
Insights into the biology and therapeutic implications of TNF and regulatory T cells.解析 TNF 和调节性 T 细胞的生物学和治疗意义。
Nat Rev Rheumatol. 2021 Aug;17(8):487-504. doi: 10.1038/s41584-021-00639-6. Epub 2021 Jul 5.
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Quinone-rich fraction of Ardisia crispa (Thunb.) A. DC roots alters angiogenic cascade in collagen-induced arthritis.富含贯叶连翘（Thunb.）A. DC 根醌的部分改变了胶原诱导性关节炎中的血管生成级联反应。
Inflammopharmacology. 2021 Jun;29(3):771-788. doi: 10.1007/s10787-021-00816-9. Epub 2021 Jun 5.
6
Peripheral Blood from Rheumatoid Arthritis Patients Shows Decreased T CD25 Expression and Reduced Frequency of Effector T Subpopulation.类风湿关节炎患者外周血 T 细胞 CD25 表达减少和效应性 T 细胞亚群频率降低。
Cells. 2021 Apr 3;10(4):801. doi: 10.3390/cells10040801.
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TNFR2: Role in Cancer Immunology and Immunotherapy.肿瘤坏死因子受体2（TNFR2）：在癌症免疫学和免疫治疗中的作用
Immunotargets Ther. 2021 Apr 21;10:103-122. doi: 10.2147/ITT.S255224. eCollection 2021.
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The role of CD4FoxP3 regulatory T cells in the immunopathogenesis of COVID-19: implications for treatment.CD4FoxP3调节性T细胞在新型冠状病毒肺炎免疫发病机制中的作用：对治疗的启示
Int J Biol Sci. 2021 Apr 10;17(6):1507-1520. doi: 10.7150/ijbs.59534. eCollection 2021.
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Evidence for tmTNF reverse signaling : Implications for an arginase-1-mediated therapeutic effect of TNF inhibitors during inflammation.跨膜肿瘤坏死因子反向信号传导的证据：炎症期间肿瘤坏死因子抑制剂通过精氨酸酶-1介导的治疗作用的意义。
iScience. 2021 Mar 21;24(4):102331. doi: 10.1016/j.isci.2021.102331. eCollection 2021 Apr 23.
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Biomarkers of Response to Biologic Therapy in Juvenile Idiopathic Arthritis.幼年特发性关节炎生物治疗反应的生物标志物
Front Pharmacol. 2021 Feb 2;11:635823. doi: 10.3389/fphar.2020.635823. eCollection 2020.
甲氨蝶呤通过去甲基化类风湿关节炎患者 FoxP3 上游增强子恢复调节性 T 细胞功能。
Arthritis Rheumatol. 2015 May;67(5):1182-92. doi: 10.1002/art.39031.
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Th17 cells are restrained by Treg cells via the inhibition of interleukin-6 in patients with rheumatoid arthritis responding to anti-tumor necrosis factor antibody therapy.在对抗肿瘤坏死因子抗体治疗有反应的类风湿性关节炎患者中，Th17细胞通过白细胞介素-6的抑制作用受到调节性T细胞的抑制。
Arthritis Rheum. 2012 Oct;64(10):3129-38. doi: 10.1002/art.34565.
5
Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.MAP 激酶信号通路中遗传变异与类风湿关节炎患者抗 TNF 治疗反应的关系。
Ann Rheum Dis. 2011 Jan;70(1):98-103. doi: 10.1136/ard.2010.133249. Epub 2010 Aug 30.
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Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents.跨膜 TNF-α：结构、功能及与抗 TNF 制剂的相互作用。
Rheumatology (Oxford). 2010 Jul;49(7):1215-28. doi: 10.1093/rheumatology/keq031. Epub 2010 Mar 1.
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Direct comparison of treatment responses, remission rates, and drug adherence in patients with rheumatoid arthritis treated with adalimumab, etanercept, or infliximab: results from eight years of surveillance of clinical practice in the nationwide Danish DANBIO registry.接受阿达木单抗、依那西普或英夫利昔单抗治疗的类风湿关节炎患者的治疗反应、缓解率和药物依从性的直接比较：丹麦全国DANBIO注册中心八年临床实践监测结果
Arthritis Rheum. 2010 Jan;62(1):22-32. doi: 10.1002/art.27227.
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Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis.白细胞介素10作用于调节性T细胞，以维持结肠炎小鼠中转录因子Foxp3的表达和抑制功能。
Nat Immunol. 2009 Nov;10(11):1178-84. doi: 10.1038/ni.1791. Epub 2009 Sep 27.
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Outside-to-inside signaling through transmembrane tumor necrosis factor reverses pathologic interleukin-1beta production and deficient apoptosis of rheumatoid arthritis monocytes.通过跨膜肿瘤坏死因子进行的由外向内信号传导可逆转类风湿性关节炎单核细胞病理性白细胞介素-1β的产生及凋亡缺陷。
Arthritis Rheum. 2009 Sep;60(9):2612-21. doi: 10.1002/art.24778.
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The inhibition of JNK and p38 MAPKs downregulates IL-10 and differentially affects c-Jun gene expression in human monocytes.JNK 和 p38 MAPKs 的抑制作用下调了人单核细胞中的 IL-10，并对 c-Jun 基因表达产生不同影响。
Immunopharmacol Immunotoxicol. 2009 Jun;31(2):195-201. doi: 10.1080/08923970802626276.