Division of Nephrology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Division of Nephrology, Department of Internal Medicine, Hsin-Jen Hospital, New Taipei City, Taiwan.
Clin Chim Acta. 2018 Oct;485:113-118. doi: 10.1016/j.cca.2018.06.025. Epub 2018 Jun 21.
Fatty acid binding protein 4 (FABP4) is found to play a role in skeletal muscle homeostasis. Since the dysregulation of FABP4 and sarcopenia are both highly prevalent in patients on chronic hemodialysis (HD), the correlation between them remains unknown. We aimed to examine this relationship in a cross-sectional study.
A total of 120 chronic HD patients were recruited, and whose skeletal muscle mass, handgrip strength, and gait speed were assessed and blood samples were obtained. We grouped these participants into sarcopenia (n = 20) and non-sarcopenia groups according to European Working Group on Sarcopenia in Older People criteria.
The sarcopenia group exhibited lower weight (P < 0.001), height (P = 0.019), waist circumference (P < 0.001), body mass index (P < 0.001), body fat mass (P = 0.004), and lower serum triglycerides (P = 0.009), creatinine (P < 0.001), phosphorus (P = 0.013), intact parathyroid hormone (P = 0.012), and FABP4 concentrations (P = 0.005), and higher malnutrition-inflammation scores (MIS) (P = 0.031), urea reduction rates (P < 0.001), and fractional clearance index for urea (Kt/V) values (P < 0.001). Serum FABP4 concentrations (odds ratio (OR): 0.98, 95% confidence interval (CI): 0.96-0.99, P = 0.043), body fat mass (OR: 0.86, 95% CI: 0.77-0.97, P = 0.013), MIS (OR: 6.90, 95% CI: 1.31-36.36, P = 0.023), and Kt/V (each increase of 0.1, OR: 2.15, 95% CI: 1.29-3.57, P = 0.003) were independent predictors of sarcopenia in chronic HD patients.
We delineated the association between serum FABP4 concentrations and sarcopenia in chronic HD patients.
脂肪酸结合蛋白 4（FABP4）在骨骼肌稳态中发挥作用。由于 FABP4 失调和肌肉减少症在慢性血液透析（HD）患者中都非常普遍，因此它们之间的相关性尚不清楚。我们旨在通过横断面研究来检验这种关系。
共招募了 120 名慢性 HD 患者，并评估了他们的骨骼肌量、握力和步态速度，并采集了血液样本。我们根据欧洲老年人肌肉减少症工作组的标准将这些参与者分为肌肉减少症（n=20）和非肌肉减少症组。
肌肉减少症组的体重（P<0.001）、身高（P=0.019）、腰围（P<0.001）、体重指数（P<0.001）、体脂肪量（P=0.004）和血清三酸甘油酯（P=0.009）、肌酐（P<0.001）、磷（P=0.013）、完整甲状旁腺激素（P=0.012）和 FABP4 浓度（P=0.005）均较低，营养不良-炎症评分（MIS）（P=0.031）、尿素减少率（P<0.001）和尿素分数清除率指数（Kt/V）值（P<0.001）均较高。血清 FABP4 浓度（比值比（OR）：0.98，95%置信区间（CI）：0.96-0.99，P=0.043）、体脂肪量（OR：0.86，95%CI：0.77-0.97，P=0.013）、MIS（OR：6.90，95%CI：1.31-36.36，P=0.023）和 Kt/V（每次增加 0.1，OR：2.15，95%CI：1.29-3.57，P=0.003）是慢性 HD 患者肌肉减少症的独立预测因素。
我们描绘了慢性 HD 患者血清 FABP4 浓度与肌肉减少症之间的关系。
