Department of Nephrology, Institute of Kidney Diseases, West China Hospital of Sichuan University, Chengdu, 610041, China.
West China School of Nursing, Sichuan University, Chengdu, 610041, China.
BMC Nephrol. 2024 Oct 29;25(1):385. doi: 10.1186/s12882-024-03836-z.
Sarcopenia, the progressive loss of muscle mass and strength, is common among patients with chronic kidney disease, especially those on maintenance hemodialysis. This condition often arises from factors like reduced physical activity and metabolic changes associated with chronic kidney disease. This study aims to assess the prevalence and severity of sarcopenia in patients on maintenance hemodialysis (MHD), focusing on probable sarcopenia and its correlations with physical activity, body mass index, and inorganic phosphorus levels.
This cross-sectional study involved 220 patients on MHD who visited to West China Hospital of Sichuan University between February and April 2023. The demographic data, body measurements, and laboratory results were retrospectively collected. Sarcopenia was assessed using the 2019 criteria from the Asian Working Group and the European Working Group on Sarcopenia in Older People, and physical activity was measured via the International Physical Activity Questionnaire.
Of the study participants, 141 (64.1%) were diagnosed with probable [110 (50.0%) or confirmed sarcopenia [31 (14.1%)], including 22 (10%) with severe sarcopenia. Multivariable logistic regression analysis revealed that physical activity (International Physical Activity Questionnaire score, OR = 0.998, 95% CI: 0.998-0.999, P < 0.001), body mass index (OR = 0.868, 95% CI: 0.788-0.957, P = 0.004), and inorganic phosphorus levels (OR = 0.513, 95% CI: 0.270-0.975, P = 0.042) independently influenced the likelihood of sarcopenia. Within the sarcopenic group, physical activity and BMI significantly correlated with the condition's severity.
The prevalence of probable or confirmed sarcopenia in patients on MHD is significant. Factors such as physical activity, body mass index, and inorganic phosphorus levels are independently associated the presence and severity of sarcopenia in this population.
Chinese Clinical Trial Registry (ChiCTR2100051111), registered on 2021-09-13.
肌肉减少症是一种肌肉质量和力量进行性丧失的病症，在慢性肾脏病患者中很常见，尤其是那些接受维持性血液透析的患者。这种情况通常是由于与慢性肾脏病相关的身体活动减少和代谢变化等因素引起的。本研究旨在评估接受维持性血液透析（MHD）的患者中肌肉减少症的患病率和严重程度，重点关注可能的肌肉减少症及其与身体活动、体重指数和无机磷水平的相关性。
这是一项横断面研究，纳入了 2023 年 2 月至 4 月期间在四川大学华西医院就诊的 220 名接受 MHD 的患者。回顾性收集了人口统计学数据、身体测量值和实验室结果。使用 2019 年亚洲工作组和欧洲老年人肌肉减少症工作组的标准评估肌肉减少症，通过国际体力活动问卷测量身体活动。
在研究参与者中，141 人（64.1%）被诊断为可能患有肌肉减少症[110 人（50.0%）或确诊肌肉减少症[31 人（14.1%）]，其中 22 人（10%）患有严重肌肉减少症。多变量逻辑回归分析显示，身体活动（国际体力活动问卷评分，OR=0.998，95%CI：0.998-0.999，P<0.001）、体重指数（OR=0.868，95%CI：0.788-0.957，P=0.004）和无机磷水平（OR=0.513，95%CI：0.270-0.975，P=0.042）独立影响肌肉减少症的可能性。在肌肉减少症组中，身体活动和 BMI 与疾病的严重程度显著相关。
接受 MHD 的患者中可能或确诊的肌肉减少症患病率较高。身体活动、体重指数和无机磷水平等因素与该人群中肌肉减少症的发生和严重程度独立相关。
中国临床试验注册中心（ChiCTR2100051111），于 2021 年 9 月 13 日注册。
