Bio-INvENT Lab, Department of Chemical Engineering, Siddaganga Institute of Technology, B.H. Road, Tumakuru, 572103, Karnataka, India.
Bio-INvENT Lab, Department of Chemical Engineering, Siddaganga Institute of Technology, B.H. Road, Tumakuru, 572103, Karnataka, India.
Adv Drug Deliv Rev. 2018 Jul;132:57-80. doi: 10.1016/j.addr.2018.06.012. Epub 2018 Jun 21.
Cellular carriers for drug delivery are attractive alternatives to synthetic nanoparticles owing to their innate homing/targeting abilities. Here, we review molecular interactions involved in the homing of Mesenchymal stem cells (MSCs) and other cell types to understand the process of designing and engineering highly efficient, actively targeting cellular vehicles. In addition, we comprehensively discuss various genetic and non-genetic strategies and propose futuristic approaches of engineering MSC homing using micro/nanotechnology and high throughput small molecule screening. Most of the targeting abilities of a cell come from its plasma membrane, thus, efforts to harness cell membranes as drug delivery vehicles are gaining importance and are highlighted here. We also recognize and report the lack of detailed characterization of cell membranes in terms of safety, structural integrity, targeting functionality, and drug transport. Finally, we provide insights on future development of bioengineered cellular and cell membrane-derived vesicles for successful clinical translation.
细胞载体作为药物递送系统，由于其固有的归巢/靶向能力，成为了合成纳米颗粒的理想替代品。在此，我们综述了间充质干细胞（MSCs）和其他细胞类型归巢过程中的分子相互作用，以了解设计和构建高效、主动靶向细胞载体的过程。此外，我们还全面讨论了各种遗传和非遗传策略，并提出了使用微/纳米技术和高通量小分子筛选工程 MSC 归巢的未来方法。细胞的大多数靶向能力来自其质膜，因此，利用质膜作为药物递送载体的努力越来越受到重视，并在此重点介绍。我们还认识到并报告了在安全性、结构完整性、靶向功能和药物运输方面对细胞膜缺乏详细的表征。最后，我们对生物工程化细胞和细胞膜衍生囊泡的未来发展提供了一些见解，以期实现成功的临床转化。
