a School of Life Science and Technology , China Pharmaceutical University , Nanjing , China.
b Department of Pharmaceutics , China Pharmaceutical University , Nanjing , China.
Artif Cells Nanomed Biotechnol. 2018;46(sup1):642-652. doi: 10.1080/21691401.2018.1434185. Epub 2018 Feb 19.
The main challenge of anticancer drugs is poor tumor targeting. Now cellular carriers are widely investigated to deliver anticancer agents. As an ideal cellular candidate, human umbilical cord derived mesenchymal stem cells (hUC-MSCs) possess inherent tropism potential to tumor. Here, we constructed hUC-MSCs carrying transferrin-inspired-nanoparticles that contain doxorubicin(hUC-MSCs-Tf-inspired-NPs) to achieve enhanced anti-tumor efficacy and made an evaluation. Results represented that hUC-MSCs-Tf-inspired-NPs not only exhibit the controlled-release property of Tf-inspired-NPs, but also integrate tumor tropism and penetrative abilities of MSCs. The tumor volume of nude mice bearing breast cancer MCF-7 treated with hUC-MSCs-Tf-inspired-NPs, was remarkably reduced compared to those treated with free drug or Tf-inspired-NPs. Thus, Tf-inspired-NPs loaded hUC-MSCs have a potential to deliver anticancer drugs.
抗癌药物的主要挑战是肿瘤靶向性差。现在，细胞载体被广泛研究用于输送抗癌药物。人脐带间充质干细胞（hUC-MSCs）作为一种理想的细胞候选物，具有对肿瘤的固有趋向性潜力。在这里，我们构建了携带转铁蛋白启发型纳米颗粒的 hUC-MSCs，其中包含阿霉素（hUC-MSCs-Tf-inspired-NPs），以实现增强的抗肿瘤疗效并进行了评估。结果表明，hUC-MSCs-Tf-inspired-NPs 不仅表现出转铁蛋白启发型纳米颗粒的控制释放特性，还整合了 MSCs 的肿瘤趋向性和穿透能力。与单独使用游离药物或转铁蛋白启发型纳米颗粒治疗的荷乳腺癌 MCF-7 裸鼠相比，用 hUC-MSCs-Tf-inspired-NPs 治疗的裸鼠的肿瘤体积明显减小。因此，负载转铁蛋白启发型纳米颗粒的 hUC-MSCs 具有输送抗癌药物的潜力。
