Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Medical School, Southeast University, Nanjing 210009, China.
School of Public Health, Southeast University, Nanjing 210009, China.
Sci Total Environ. 2018 Dec 1;643:119-126. doi: 10.1016/j.scitotenv.2018.06.173. Epub 2018 Jun 21.
In this study, we employed Caenorhabditis elegans with acs-22 mutation to examine the in vivo effect of functional deficit in intestinal barrier on toxicity and translocation of nanopolystyrene particles. Mutation of acs-22 leads to deficit in intestinal barrier. After prolonged exposure, nanopolystyrene particles at concentrations ≥1 μg/L could cause toxicity on acs-22 mutant nematodes. acs-22 mutation resulted in translocation of nanopolystyrene particles into targeted organs through intestinal barrier in nanopolystyrene particles (1 μg/L) exposed nematodes. After prolonged exposure, nanopolystyrene particles (1 μg/L) dysregulated expressions of some genes required for the control of oxidative stress and activated expression of Nrf signaling pathway. Therefore, under certain pathological conditions, our results suggest the potential toxicity of nanoplastic particles at predicted environmental concentration on organisms after long-term exposure.
在这项研究中，我们利用 acs-22 突变的秀丽隐杆线虫来研究肠道屏障功能缺陷对纳米聚苯乙烯颗粒毒性和易位的体内影响。acs-22 的突变导致肠道屏障缺陷。经过长时间暴露，浓度≥1μg/L 的纳米聚苯乙烯颗粒会对 acs-22 突变线虫造成毒性。acs-22 突变导致纳米聚苯乙烯颗粒（1μg/L）暴露线虫中的纳米聚苯乙烯颗粒穿过肠道屏障易位到靶向器官。经过长时间暴露，纳米聚苯乙烯颗粒（1μg/L）会扰乱一些控制氧化应激所需基因的表达，并激活 Nrf 信号通路的表达。因此，在某些病理条件下，我们的结果表明，在长期暴露后，预测环境浓度下的纳米塑料颗粒对生物体具有潜在的毒性。
