Department of Neuroscience, Canadian Center for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada; Department of Basic Sciences in Rehabilitation, School of Rehabilitation Sciences, Iran University of Medical Science (IUMS), Tehran, Iran.
Department of Neuroscience, Canadian Center for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada.
Exp Neurol. 2018 Oct;308:1-12. doi: 10.1016/j.expneurol.2018.06.011. Epub 2018 Jun 22.
Although traffic noise exposure is a well-known environmental pollutant whose negative health effect has been discussed in different aspects of the human life, only a few animal studies have tackled this issue as a cohort study, which is not feasible to be addressed in human studies. In addition to the deleterious impact of the daytime noise on well-being, chronic nocturnal noise can also disturb sleep and affects physical and mental health, but to date, little research has examined the neurobiological effects of light/dark cycles of traffic noise exposure. We investigated the effects of light/dark cycles and sex on the impact of chronic traffic noise exposure on mouse brain structure-function. The mice were randomly assigned to either one of two stress conditions or a control condition. Animals were exposed to traffic noise on either the light-cycle (LC) or dark-cycle (DC) for 30 days. Traffic noise exposure caused the hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, anxiety-like behavior, impairments in learning and memory, dysfunction in balance and motor coordination, and a reduction in variety of brain measures including a brain volume, medial prefrontal cortex (mPFC) area, cortical thickness, hippocampal volume, amygdala area, and the neural density in mPFC and dentate gyrus. All behavioral and brain measures revealed adverse effects of the chronic noise stress irrespective of the LC/DC exposure or sex. Our findings were a re-emphasis on the significance of noise prevention and mitigation strategies for public health.
尽管交通噪声暴露是一种众所周知的环境污染物，其对健康的负面影响已在人类生活的不同方面进行了讨论，但只有少数动物研究将其作为队列研究来解决这个问题，而这在人类研究中是不可行的。除了白天噪声对幸福感的有害影响外，慢性夜间噪声还会干扰睡眠并影响身心健康，但迄今为止，很少有研究探讨交通噪声暴露昼夜循环的神经生物学效应。我们研究了光/暗循环和性别对慢性交通噪声暴露对小鼠大脑结构-功能影响的作用。将小鼠随机分配到两种应激条件之一或对照条件之一。动物在光照周期（LC）或黑暗周期（DC）下接受交通噪声暴露 30 天。交通噪声暴露导致下丘脑-垂体-肾上腺（HPA）轴活性亢进、焦虑样行为、学习和记忆受损、平衡和运动协调功能障碍，以及多种大脑测量值减少，包括大脑体积、内侧前额叶皮质（mPFC）面积、皮质厚度、海马体积、杏仁核面积以及 mPFC 和齿状回的神经密度。所有行为和大脑测量值均显示出慢性噪声应激的不利影响，而与 LC/DC 暴露或性别无关。我们的研究结果再次强调了噪声预防和缓解策略对公共健康的重要性。
