重复性头部撞击对碰撞运动中神经生物学的影响。
The neurobiological effects of repetitive head impacts in collision sports.
机构信息
The Gruss Magnetic Resonance Imaging Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
The Gruss Magnetic Resonance Imaging Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA; Departments of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA; Departments of Physiology and Biophysics, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
出版信息
Neurobiol Dis. 2019 Mar;123:122-126. doi: 10.1016/j.nbd.2018.06.016. Epub 2018 Jun 21.
Abstract
It is now recognized that repetitive head impacts (RHI) in sport have the potential for long-term neurological impairments. In order to identify targets for intervention and/or pharmacological treatment, it is necessary to characterize the neurobiological mechanisms associated with RHI. This review aims to summarize animal and human studies that specifically address Blood Brain Barrier (BBB) dysfunction, abnormal neuro-metabolic and neuro-inflammatory processes as well as Tau aggregation associated with RHI in collision sports. Additionally, we examine the influence of physical activity and genetics on outcomes of RHI, discuss methodological considerations, and provide suggestions for future directions of this burgeoning area of research.
摘要
现在人们已经认识到，运动中的重复性头部冲击（RHI）有可能造成长期的神经损伤。为了确定干预和/或药物治疗的靶点，有必要描述与 RHI 相关的神经生物学机制。本综述旨在总结专门针对碰撞运动中 RHI 相关的血脑屏障（BBB）功能障碍、异常神经代谢和神经炎症过程以及 Tau 聚集的动物和人类研究。此外，我们还研究了体育活动和遗传因素对 RHI 结果的影响，讨论了方法学方面的考虑，并为这一新兴研究领域提供了未来的发展方向。
相似文献
1
The neurobiological effects of repetitive head impacts in collision sports.重复性头部撞击对碰撞运动中神经生物学的影响。
Neurobiol Dis. 2019 Mar;123:122-126. doi: 10.1016/j.nbd.2018.06.016. Epub 2018 Jun 21.
2
Neurometabolic aspects of sports-related concussion.与运动相关的脑震荡的神经代谢方面
Semin Speech Lang. 2014 Aug;35(3):159-65. doi: 10.1055/s-0034-1384677. Epub 2014 Aug 12.
3
Repetitive head impacts do not affect postural control following a competitive athletic season.重复性头部撞击不会影响竞技赛季后的姿势控制。
Int J Psychophysiol. 2018 Oct;132(Pt A):81-86. doi: 10.1016/j.ijpsycho.2017.09.018. Epub 2017 Oct 3.
4
Long-Term Cognitive and Neuropsychiatric Consequences of Repetitive Concussion and Head-Impact Exposure.重复性脑震荡和头部撞击暴露的长期认知和神经精神后果。
J Athl Train. 2017 Mar;52(3):309-317. doi: 10.4085/1062-6050-52.1.14.
5
An anatomical and physiological basis for the cardiovascular autonomic nervous system consequences of sport-related brain injury.运动相关性脑损伤对心血管自主神经系统影响的解剖学和生理学基础。
Int J Psychophysiol. 2018 Oct;132(Pt A):155-166. doi: 10.1016/j.ijpsycho.2017.11.016. Epub 2017 Nov 29.
6
It's Not All Fun and Games: Sports, Concussions, and Neuroscience.并非全是乐趣和游戏：运动、脑震荡和神经科学。
Neuron. 2017 Jun 21;94(6):1051-1055. doi: 10.1016/j.neuron.2017.05.003.
7
The new neurometabolic cascade of concussion.脑震荡的新神经代谢级联反应。
Neurosurgery. 2014 Oct;75 Suppl 4(0 4):S24-33. doi: 10.1227/NEU.0000000000000505.
8
Subconcussive head impacts in sport: A systematic review of the evidence.运动中的亚脑震荡性头部撞击：证据的系统评价。
Int J Psychophysiol. 2018 Oct;132(Pt A):39-54. doi: 10.1016/j.ijpsycho.2018.01.007. Epub 2018 Feb 3.
9
The pathophysiology of concussions in youth.青少年脑震荡的病理生理学
Phys Med Rehabil Clin N Am. 2011 Nov;22(4):577-602, vii. doi: 10.1016/j.pmr.2011.08.002. Epub 2011 Sep 25.
10
Epidemiology and pathophysiology of minor traumatic brain injury.轻度创伤性脑损伤的流行病学与病理生理学
Curr Sports Med Rep. 2003 Feb;2(1):18-23. doi: 10.1249/00149619-200302000-00005.
引用本文的文献
1
Annual level changes of serum neuronal and glial biomarkers in a German professional football club.德国一家职业足球俱乐部中血清神经元和神经胶质生物标志物的年度水平变化
J Neurol. 2025 Jun 13;272(7):461. doi: 10.1007/s00415-025-13176-z.
2
Unlocking the Impact: A Systematic Review and Meta-Analysis of Biomechanical Insights into Rugby Head Impacts Using Wearable Sensor Technology.揭示影响：使用可穿戴传感器技术对橄榄球头部撞击生物力学见解的系统评价与荟萃分析
Sports Med. 2025 May 3. doi: 10.1007/s40279-025-02228-z.
3
Youth Soccer Heading Exposure and Its Effects on Clinical Outcome Measures.青少年足球头球暴露及其对临床结局指标的影响。
Sports (Basel). 2024 Dec 10;12(12):342. doi: 10.3390/sports12120342.
4
Levels of biomarkers associated with subconcussive head hits in mixed martial arts fighters.与混合武术格斗运动员亚脑震荡性头部撞击相关的生物标志物水平。
PeerJ. 2024 Aug 28;12:e17752. doi: 10.7717/peerj.17752. eCollection 2024.
5
Anisotropy component of DTI reveals long-term neuroinflammation following repetitive mild traumatic brain injury in rats.DTI 的各向异性成分揭示了大鼠反复轻度创伤性脑损伤后的长期神经炎症。
Eur Radiol Exp. 2024 Jul 24;8(1):82. doi: 10.1186/s41747-024-00490-w.
6
Quantifying the Magnitude and Longevity of the Effect of Repetitive Head Impacts in Adolescent Soccer Players: Deleterious Effect of Long Headers Extend Beyond a Month.量化青少年足球运动员反复头部撞击的影响程度和持续时间：长传冲吊的有害影响持续超过一个月。
Neurotrauma Rep. 2023 Apr 21;4(1):267-275. doi: 10.1089/neur.2022.0085. eCollection 2023.
7
Repetitive soccer heading adversely impacts short-term learning among adult women.重复性足球头球会对成年女性的短期学习产生不利影响。
J Sci Med Sport. 2022 Nov;25(11):935-941. doi: 10.1016/j.jsams.2022.08.011. Epub 2022 Aug 26.
8
Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries.大鼠颅骨对反复轻度创伤性脑损伤的局部、时相关反应。
Sci Rep. 2022 Sep 1;12(1):14175. doi: 10.1038/s41598-022-18643-5.
9
A Systematic Review of Head Impacts and Acceleration Associated with Soccer.足球运动中头部撞击和加速度的系统评价
Int J Environ Res Public Health. 2022 May 1;19(9):5488. doi: 10.3390/ijerph19095488.
10
Understanding and Managing Trauma-Induced Vestibular Deficits.理解和管理创伤性前庭功能障碍。
J Int Adv Otol. 2021 Nov;17(6):559-565. doi: 10.5152/iao.2021.21258.
本文引用的文献
1
The association between BDNF Val66Met polymorphism and emotional symptoms after mild traumatic brain injury.脑源性神经营养因子Val66Met多态性与轻度创伤性脑损伤后情绪症状的关联
BMC Med Genet. 2018 Jan 22;19(1):13. doi: 10.1186/s12881-017-0518-0.
2
The Effect of Pretest Exercise on Baseline Computerized Neurocognitive Test Scores.预测试运动对基线计算机化神经认知测试分数的影响。
Orthop J Sports Med. 2017 Oct 23;5(10):2325967117734496. doi: 10.1177/2325967117734496. eCollection 2017 Oct.
3
Acute Changes in Plasma Total Tau Levels Are Independent of Subconcussive Head Impacts in College Football Players.血浆总 tau 水平的急性变化与大学生足球运动员的亚临床性头部撞击无关。
J Neurotrauma. 2018 Jan 15;35(2):260-266. doi: 10.1089/neu.2017.5376. Epub 2017 Dec 18.
4
Repeated Mild Traumatic Brain Injury: Potential Mechanisms of Damage.重复轻度创伤性脑损伤：潜在的损伤机制。
Cell Transplant. 2017 Jul;26(7):1131-1155. doi: 10.1177/0963689717714092.
5
A review of the effects of physical activity and sports concussion on brain function and anatomy.体育活动和运动性脑震荡对大脑功能和解剖结构影响的综述。
Int J Psychophysiol. 2018 Oct;132(Pt A):167-175. doi: 10.1016/j.ijpsycho.2017.09.005. Epub 2017 Sep 8.
6
Structural, Functional, and Metabolic Brain Markers Differentiate Collision versus Contact and Non-Contact Athletes.结构、功能和代谢性脑标志物可区分碰撞性与接触性及非接触性运动员。
Front Neurol. 2017 Aug 22;8:390. doi: 10.3389/fneur.2017.00390. eCollection 2017.
7
Long-Term Kinetics of Immunologic Components and Neurological Deficits in Rats Following Repetitive Mild Traumatic Brain Injury.重复性轻度创伤性脑损伤后大鼠免疫成分的长期动力学及神经功能缺损
Med Sci Monit. 2017 Apr 8;23:1707-1718. doi: 10.12659/msm.901124.
8
Astroglial activation and altered amyloid metabolism in human repetitive concussion.人类重复性脑震荡中的星形胶质细胞激活与淀粉样蛋白代谢改变
Neurology. 2017 Apr 11;88(15):1400-1407. doi: 10.1212/WNL.0000000000003816. Epub 2017 Mar 10.
9
Repetitive head impact exposure and later-life plasma total tau in former National Football League players.前美国国家橄榄球联盟球员反复头部撞击暴露与晚年血浆总tau蛋白水平的关系
Alzheimers Dement (Amst). 2016 Dec 10;7:33-40. doi: 10.1016/j.dadm.2016.11.003. eCollection 2017.
10
Emerging Roles for the Immune System in Traumatic Brain Injury.免疫系统在创伤性脑损伤中的新作用
Front Immunol. 2016 Dec 5;7:556. doi: 10.3389/fimmu.2016.00556. eCollection 2016.
Zotero 插件