Appalachian State University, Beaver College of Health Sciences, 261 Locust Street, Boone, NC 28608, USA.
Appalachian State University, Beaver College of Health Sciences, 261 Locust Street, Boone, NC 28608, USA.
Drug Discov Today. 2018 Sep;23(9):1680-1688. doi: 10.1016/j.drudis.2018.06.013. Epub 2018 Jun 21.
Here, we provide a comprehensive study related to the risks of all biopharmaceutical firms going public in the USA between 1996 and 2015. We found 355 firms that met our requirements for being in the sector that focuses on creating drugs for humans. Collectively, these firms spent approximately US$86.9 billion on research and development (R&D) during this time. They also lost approximately US$69.3 billion in combined net income. We also examine the delisting of these firms from a public market, their number of collaborators at the initial public offering (IPO), and estimate the percentage ownership by other biopharmaceutical firms at the IPO.
在这里，我们提供了一项关于 1996 年至 2015 年期间在美国上市的所有生物制药公司风险的综合研究。我们发现了 355 家符合我们要求的公司，这些公司专注于开发治疗人类疾病的药物。这些公司在此期间共投入约 869 亿美元用于研发。它们的合并净亏损也约为 693 亿美元。我们还研究了这些公司从公开市场退市、首次公开募股 (IPO) 的合作伙伴数量，并估计了其他生物制药公司在 IPO 时的持股比例。
