无填充物胸壁乳房切除术后放射治疗的临床优势
Clinical Advantage of Chest-wall Post-mastectomy Radiation Therapy Without Bolus.
作者信息
Shiba Shintaro, Okamoto Masahiko, Kiyohara Hiroki, Okano Naoko, Yoshimoto Yuya, Murata Hiroto, Irie Daisuke, Katoh Hiroyuki, Nakano Takashi
机构信息
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan.
Department of Radiation Oncology, Gunma University Graduate School of Medicine, Gunma, Japan
出版信息
In Vivo. 2018 Jul-Aug;32(4):961-965. doi: 10.21873/invivo.11335.
BACKGROUND/AIM: The clinical outcomes of post-mastectomy radiation therapy (PMRT) without bolus remain to be fully examined, so that we evaluated clinical outcomes of PMRT without bolus and to measure the chest-wall dose surface histogram (DSH) parameters.
PATIENTS AND METHODS
Fifty-two patients with breast cancer who received PMRT without bolus were retrospectively analyzed. DSH values of the percentage of maximum dose (D) were measured.
RESULTS
All patients completed the treatment; the median follow-up period was 22.1 months. The 2-year overall survival and local control rates were 85% and 95%. Five patients developed grade 2 acute radiation dermatitis, and none developed grade 2 or higher late radiation dermatitis. The median D in patients who developed grade 0-1 and grade 2 acute radiation dermatitis was 5,178 and 5,365 cGy (p=0.03).
CONCLUSION
PMRT without bolus resulted in a low frequency of grade 2 or higher radiation dermatitis without increasing locoregional recurrences, and the D was the contributing factor for developing acute radiation dermatitis.
背景/目的：未使用填充物的乳房切除术后放射治疗（PMRT）的临床结果仍有待充分研究，因此我们评估了未使用填充物的PMRT的临床结果，并测量胸壁剂量表面直方图（DSH）参数。
患者与方法
对52例接受未使用填充物的PMRT的乳腺癌患者进行回顾性分析。测量最大剂量百分比（D）的DSH值。
结果
所有患者均完成治疗；中位随访期为22.1个月。2年总生存率和局部控制率分别为85%和95%。5例患者发生2级急性放射性皮炎，无患者发生2级或更高级别的晚期放射性皮炎。发生0-1级和2级急性放射性皮炎患者的中位D分别为5178和5365 cGy（p=0.03）。
结论
未使用填充物的PMRT导致2级或更高级别放射性皮炎的发生率较低，且未增加局部区域复发率，D是发生急性放射性皮炎的影响因素。
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