Department of Nephrology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Institute of Nephrology, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Front Med. 2019 Dec;13(6):741-746. doi: 10.1007/s11684-017-0579-7. Epub 2018 Jun 23.
Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD). The relationship between HUA and white blood cell (WBC) count remains unknown. A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014. CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min∙1.73 m). HUA was defined as serum uric acid > 420 μmol/L in men and > 360 μmol/L in women. This study included 1024 participants. The prevalence of HUA was 17.77%. Patients with HUA were more likely to have higher levels of WBC count, which was positively associated with HUA prevalence. This association was also observed in participants without CKD, diabetes mellitus, hyperlipidemia, or obesity. Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants. Compared with participants without HUA, inflammatory factors such as high-sensitivity C-reactive protein, tumor necrosis factor-α, and interleukin 6 increased in participants with HUA. Hence, WBC count is positively associated with HUA, and this association is independent of conventional risk factors for CKD.
高尿酸血症（HUA）是慢性肾脏病（CKD）的危险因素。HUA 与白细胞（WBC）计数之间的关系尚不清楚。2012 年和 2014 年在三林社区进行了 CKD 抽样调查。CKD 的定义为至少处于微量白蛋白尿阶段的蛋白尿或估计的肾小球滤过率（eGFR）为 60 mL/（min·1.73 m）。HUA 的定义为男性血清尿酸>420 μmol/L，女性>360 μmol/L。本研究纳入了 1024 名参与者。HUA 的患病率为 17.77%。患有 HUA 的患者更有可能出现更高水平的 WBC 计数，且与 HUA 患病率呈正相关。在没有 CKD、糖尿病、高血脂或肥胖的参与者中也观察到了这种关联。多变量 logistic 回归分析显示，WBC 计数与男性和女性参与者患 HUA 的风险独立相关。与没有 HUA 的参与者相比，HUA 参与者的炎症因子（如高敏 C 反应蛋白、肿瘤坏死因子-α 和白细胞介素 6）升高。因此，WBC 计数与 HUA 呈正相关，这种关联独立于 CKD 的常规危险因素。
