Chao Yu-Lin, Wu Pei-Yu, Huang Jiun-Chi, Chiu Yi-Wen, Lee Jia-Jung, Chen Szu-Chia, Chang Jer-Ming, Hwang Shang-Jyh, Chen Hung-Chun
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan.
Biomedicines. 2022 Apr 13;10(4):892. doi: 10.3390/biomedicines10040892.
The incidence of hepatic steatosis is increasing globally, and it is important to identify those at risk to prevent comorbidities. Complete blood count is a simple, convenient, and inexpensive laboratory examination which can be used to obtain white blood cell (WBC) and platelet counts. The aims of this study were to investigate the relationships between WBC and platelet counts with hepatic steatosis, and whether WBC and platelet counts were associated with the severity of hepatic steatosis. We enrolled 1969 participants residing in southern Taiwan who took part in a health survey from June 2016 to September 2018 in this cross-sectional study. None of the participants were heavy alcohol users or had a history of hepatitis B or C. We collected laboratory data, and the severity of hepatic steatosis was determined by abdominal ultrasound. The overall prevalence rate of hepatic steatosis was 42.0%. There were significant trends of stepwise increases in WBC count (p < 0.001) corresponding to the severity of hepatic steatosis. After multivariable linear regression analysis, hepatic steatosis was significantly associated with high WBC count (coefficient β, 0.209; 95% confidence interval (CI), 0.055 to 0.364; p = 0.008) and high platelet count (coefficient β, 12.213; 95% CI, 6.092 to 18.334; p < 0.001); also, higher WBC counts corresponded with the severity of hepatic steatosis.
全球范围内，肝脂肪变性的发病率正在上升，识别有风险的人群以预防合并症很重要。全血细胞计数是一种简单、便捷且经济的实验室检查，可用于获取白细胞（WBC）和血小板计数。本研究的目的是调查白细胞和血小板计数与肝脂肪变性之间的关系，以及白细胞和血小板计数是否与肝脂肪变性的严重程度相关。在这项横断面研究中，我们纳入了1969名居住在台湾南部、于2016年6月至2018年9月参加健康调查的参与者。所有参与者均非重度饮酒者，也没有乙肝或丙肝病史。我们收集了实验室数据，肝脂肪变性的严重程度通过腹部超声确定。肝脂肪变性的总体患病率为42.0%。白细胞计数随着肝脂肪变性严重程度的增加呈显著的逐步上升趋势（p < 0.001）。经过多变量线性回归分析，肝脂肪变性与高白细胞计数（系数β，0.209；95%置信区间（CI），0.055至0.364；p = 0.008）和高血小板计数（系数β，12.213；95% CI，6.092至18.334；p < 0.001）显著相关；此外，白细胞计数越高，肝脂肪变性的严重程度越高。
