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原位恶性雀斑样痣黑色素瘤的分期切缘控制切除术(SMEX)

Staged margin-controlled excision (SMEX) for lentigo maligna melanoma in situ.

作者信息

Beveridge Julie, Taher Muba, Zhu Jay, Mahmood Muhammad N, Salopek Thomas G

机构信息

Division of Plastic Surgery, University of Alberta, Edmonton, Alberta, Canada.

Division of Dermatology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

出版信息

J Surg Oncol. 2018 Jul;118(1):144-149. doi: 10.1002/jso.25109. Epub 2018 Jun 24.

Abstract

BACKGROUND

No consensus exists regarding the best surgical strategy to achieve clear surgical margins while minimizing tissue excision when definitely excising lentigo maligna melanoma in situ (LM). The staged margin controlled excision (SMEX) technique is a modification of the spaghetti technique that allows surgeons to minimize margins and ensure complete excision of LM.

OBJECTIVES

Our objectives were twofold: a) to evaluate the effectiveness of SMEX for treatment of LM and b) detail the SMEX technique.

METHODS

A retrospective chart review of adult patients who underwent the SMEX technique for treatment of LM from 2011 to 2016 was conducted.

RESULTS

Twenty-four patients were identified with predominantly facial lesions. The mean defect size was 12.1 cm . A mean number of two SMEX procedures, with an average margin of 9 mm, were required to obtain complete excision of the LM. Using SMEX, we achieved 100% clearance of LM over a median follow up period of 18 months, with a range of 1-63 months.

CONCLUSIONS

SMEX offers a reliable surgical excision method that ensures complete excision of LM in a cosmetically sensitive manner. The recurrence outcomes of SMEX are comparable, if not better, than those of alternative excision techniques in the literature.

摘要

背景

在明确切除原位恶性雀斑样痣黑色素瘤(LM)时,对于既能实现手术切缘阴性又能尽量减少组织切除量的最佳手术策略,目前尚无共识。分期切缘控制切除术(SMEX)技术是对意大利面条技术的一种改良,它能让外科医生尽量缩小切缘并确保完整切除LM。

目的

我们的目的有两个:a)评估SMEX治疗LM的有效性;b)详细介绍SMEX技术。

方法

对2011年至2016年接受SMEX技术治疗LM的成年患者进行回顾性病历审查。

结果

共确定了24例患者,主要病变位于面部。平均缺损面积为12.1平方厘米。平均需要进行两次SMEX手术,平均切缘为9毫米,才能完整切除LM。使用SMEX,在中位随访期18个月(范围为1 - 63个月)内,我们实现了LM的100%清除率。

结论

SMEX提供了一种可靠的手术切除方法,能以美观敏感的方式确保完整切除LM。SMEX的复发结果与文献中其他切除技术相比,即便不比其更好,也不相上下。

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