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分期切除恶性雀斑样痣和恶性黑素瘤:十年经验。

Staged excision of lentigo maligna and lentigo maligna melanoma: a 10-year experience.

机构信息

Milwaukee, Wis. From the Departments of Plastic Surgery and Dermatology, Medical College of Wisconsin.

出版信息

Plast Reconstr Surg. 2009 Dec;124(6):1947-1955. doi: 10.1097/PRS.0b013e3181bcf002.

Abstract

BACKGROUND

The treatment of lentigo maligna and lentigo maligna melanoma presents a difficult problem for clinicians. Published guidelines recommend a 5-mm excision margin for lentigo maligna and a 1-cm margin for lentigo maligna melanoma, yet these are often inadequate. The authors' purpose is to report their 10-year experience using staged excision for the treatment of lentigo maligna and lentigo maligna melanoma of the head and neck.

METHODS

Staged excision was performed on 59 patients over a 10-year period. Data on patient demographics, lesion characteristics, and treatment were collected through an institutional review board-approved chart review.

RESULTS

Using staged excision, 62.7 percent of patients required a 10-mm or greater margin to achieve clearance of tumor. Two or more stages of excision were required in 50.9 percent of patients. Invasive melanoma (lentigo maligna melanoma) was identified in 10.2 percent of patients initially diagnosed with lentigo maligna. There was one (1.7 percent) documented recurrence during a median 2.25-year follow-up period (range, 0 to 10.17 years).

CONCLUSIONS

Staged excision is an effective treatment for lentigo maligna and lentigo maligna melanoma. Previously published recommendations of 5-mm margins for wide local excision are inadequate for tumors located on the head and neck.

摘要

背景

恶性雀斑样痣和恶性雀斑样黑素瘤的治疗对临床医生来说是一个难题。已发表的指南建议对恶性雀斑样痣行 5mm 切除边缘,对恶性雀斑样黑素瘤行 1cm 切除边缘,但这些通常是不够的。作者的目的是报告他们使用分期切除治疗头颈部恶性雀斑样痣和恶性雀斑样黑素瘤的 10 年经验。

方法

在 10 年期间对 59 例患者进行了分期切除。通过机构审查委员会批准的图表审查收集了患者人口统计学、病变特征和治疗数据。

结果

使用分期切除,62.7%的患者需要 10mm 或更大的边缘才能清除肿瘤。50.9%的患者需要进行两期或更多期的切除。在最初诊断为恶性雀斑样痣的患者中,有 10.2%被发现存在侵袭性黑素瘤(恶性雀斑样黑素瘤)。在中位 2.25 年(范围 0 至 10.17 年)的随访期间,有 1 例(1.7%)记录到复发。

结论

分期切除是治疗恶性雀斑样痣和恶性雀斑样黑素瘤的有效方法。先前发表的建议对位于头颈部的肿瘤进行广泛局部切除时,5mm 边缘的建议是不够的。

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