Jin P F, Li J X, Zhu F C
Institute for Clinical Evaluation of Vaccines, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2018 Jun 10;39(6):862-866. doi: 10.3760/cma.j.issn.0254-6450.2018.06.032.
The importance of vaccine on public health is related to the herd protection related to the levels of vaccine coverage, which directly influences the vaccinated individuals as well as the unvaccinated community. Reaching the level of herd protection by increasing vaccine coverage is the basic strategy to eradicate related infectious diseases. Again, herd protection has played an important role in public health practices. With the increasing interests in estimating the vaccine herd protection, we however, have seen only few relevant papers including observational population-based and cluster-randomized clinical trials reported in China. We hope to discuss the study designs for evaluating the vaccine herd protection in order to generate evidence-based related research in this field.
疫苗对公共卫生的重要性与疫苗接种覆盖率相关的群体保护有关,这直接影响到接种疫苗的个体以及未接种疫苗的社区。通过提高疫苗接种覆盖率达到群体保护水平是根除相关传染病的基本策略。同样,群体保护在公共卫生实践中发挥了重要作用。然而,随着对评估疫苗群体保护的兴趣日益增加,我们在中国仅看到少数相关论文,包括基于观察性人群和整群随机临床试验的报告。我们希望讨论评估疫苗群体保护的研究设计,以便在该领域开展基于证据的相关研究。