Albeshan Salman M, Hossain Syeda Z, Mackey Martin G, Demchig Delgermaa, Peat Jennifer K, Brennan Patrick C
Medical Radiation Sciences, Medical Image Optimization and Perception Group (MIOPeG), Faculty of Health Sciences, University of Sydney, Sydney, New South Wales, Australia.
Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University (KSU), Kingdom of Saudi Arabia. Email:
Asian Pac J Cancer Prev. 2018 Jun 25;19(6):1607-1616. doi: 10.22034/APJCP.2018.19.6.1607.
Objective: Mammographic density is an important risk factor for breast cancer and determines to a large extent mammographic screening efficacy. This study aims to provide baseline data for mammographic density profiling of women living in Ras Al Khaimah (RAK) and to identify risk factors associated with high mammographic density. Methods: A cross-sectional design was used to examine a series of 366 mammography cases. The Breast Imaging Reporting and Data System (BI-RADS, 5th edition) was used to evaluate mammographic density. Pearson’s chi-squared, Mann-Whitney U test and multivariate logistic regression were used for statistical analysis. Results: Most participants (67%) fell into BI-RADS b and c mammographic density categories. Of the total sample, women who were aged ≤ 45 years (p=0.004, OR=1.9), weighed ≤ 71kg (p=<0.0001, OR=4.8), had a body mass index of ≤ 27 kg/m2 (p=<0.0001, OR=5.1) and were of non-Arab descent (p=0.007, OR=1.8) were significantly more likely to have denser breast tissue. Adjusted ethnicity regression analysis showed that Emirati women were significantly less likely to have dense breast tissue compared with Western women (p=0.04, OR=0.4). Among the sample of survey participants, increased odds of having mammographic density were among women who were full-time workers (p=0.02, OR=2.8), of Christian faith (p=0.007, OR=4.4), nulliparous (p=0.003, OR=10.8), had three or fewer children (p=0.03, OR=3.8), and had used oral contraceptives for three years or more (p=0.01, OR=6.1). Conclusion: This study indicated that because Emirati women have a low mammographic density profile, screening mammography can be considered as an effective early detection imaging modality.
乳腺钼靶密度是乳腺癌的一个重要风险因素，在很大程度上决定了乳腺钼靶筛查的效果。本研究旨在提供哈伊马角（RAK）女性乳腺钼靶密度特征的基线数据，并确定与高乳腺钼靶密度相关的风险因素。方法：采用横断面设计对366例乳腺钼靶检查病例进行研究。使用乳腺影像报告和数据系统（BI-RADS，第5版）评估乳腺钼靶密度。采用Pearson卡方检验、Mann-Whitney U检验和多因素逻辑回归进行统计分析。结果：大多数参与者（67%）的乳腺钼靶密度属于BI-RADS b和c类别。在总样本中，年龄≤45岁（p=0.004，OR=1.9）、体重≤71kg（p<0.0001，OR=4.8）、体重指数≤27kg/m²（p<0.0001，OR=5.1）以及非阿拉伯血统（p=0.007，OR=1.8）的女性乳腺组织密度较高的可能性显著更高。校正种族的回归分析显示，与西方女性相比，阿联酋女性乳腺组织密度较高的可能性显著更低（p=0.04，OR=0.4）。在调查参与者样本中，全职工作的女性（p=0.02，OR=2.8）、基督教信仰者（p=0.007，OR=4.4）、未生育过的女性（p=0.003，OR=10.8）、生育三个或更少孩子的女性（p=0.03，OR=3.8）以及使用口服避孕药三年或更长时间的女性（p=0.01，OR=6.1）乳腺钼靶密度较高的几率增加。结论：本研究表明，由于阿联酋女性乳腺钼靶密度较低，乳腺钼靶筛查可被视为一种有效的早期检测成像方式。
