Department of Chemistry and Biochemistry , National Chung Cheng University , 168 University Road , Minhsiung, Chiayi 62102 , Taiwan , Republic of China.
Anal Chem. 2018 Jul 17;90(14):8320-8325. doi: 10.1021/acs.analchem.8b01763. Epub 2018 Jul 2.
We are demonstrating here the successful development of an ionic liquid device based on affinity ionic liquids AIL 1-6 tailored for chemoselective detection of gaseous chemical warfare agent (CWA) mimics on a quartz crystal microbalance (QCM) as well as on disposable filter papers. In the QCM platform, the negligible vapor pressure of ionic liquids ensures that AILs do not dry out on quartz chips and are used free of leakage during the measurements. This lack of vapor pressure makes these ionic liquid devices highly attractive for gas analysis. In the present study, chemoselective CWA mimic vapor detection by QCM occurs when gas rapidly diffuses into the AIL thin film and accordingly the nucleophilic substitution reaction emerges under the experimental conditions developed. Our initial results give credence to three important conclusions: (i) AILs could be prepared in short synthetic steps and are remarkable in detecting CWA mimics, (ii) the analysis of gaseous CWA mimics on QCM is label-free and chemoselective, and (iii) the detection of CWA mimic vapor by AILs on filter paper discs is colorimetric and portable, and, once used, the paper disc can be disposed. To the best of our knowledge, this is the first report in the literature based on the CWA mimic vapor detection in ionic liquids on a QCM.
我们在这里展示了一种基于亲和离子液体（AIL）1-6 的离子液体器件的成功开发，该器件专为在石英晶体微天平（QCM）以及一次性滤纸上对气态化学战剂（CWA）模拟物进行化学选择性检测而设计。在 QCM 平台上，离子液体的可忽略蒸气压确保 AIL 不会在石英芯片上干燥，并且在测量过程中不会泄漏。这种低蒸气压使这些离子液体器件非常适合气体分析。在本研究中，当气体快速扩散到 AIL 薄膜中时，通过 QCM 发生对 CWA 模拟物的化学选择性蒸气检测，并且相应地在开发的实验条件下出现亲核取代反应。我们的初步结果证实了三个重要结论：（i）AIL 可以通过短的合成步骤制备，并且在检测 CWA 模拟物方面表现出色，（ii）在 QCM 上对气态 CWA 模拟物的分析是无标记的和化学选择性的，以及（iii）通过 AIL 在滤纸盘上检测 CWA 模拟物蒸气是比色的和便携式的，并且一旦使用，纸盘可以被处理。据我们所知，这是文献中首次基于 QCM 上离子液体中 CWA 模拟物蒸气检测的报告。
