14型肺炎链球菌抗血清对III型B族链球菌的调理活性及体内保护作用的证明。
Demonstration of opsonic activity and in vivo protection against group B streptococci type III by Streptococcus pneumoniae type 14 antisera.
作者信息
Fischer G W, Lowell G H, Crumrine M H, Bass J W
出版信息
J Exp Med. 1978 Sep 1;148(3):776-86. doi: 10.1084/jem.148.3.776.
Abstract
The present studies demonstrate that antisera directed against Streptococcus pneumoniae type 14 is opsonic for group B streptococci type III in a neutrophile-mediated bactericidal assay. Specificity was demonstrated by the observations that group B streptococci type III and S. pneumoniae type 14 adsorbed the opsonic activity of anti-S. pneumoniae type 14 antisera. Group B streptococci strain 090R (devoid of type antigens) and S. pneumoniae type 3, did not remove the opsonic activity of anti-S. pneumoniae type 14 serum. In vivo studies using a suckling rat model of neonatal group B streptococcal type III sepsis demonstrated that antisera directed against S. pneumoniae type 14 was highly protective.
摘要
目前的研究表明，在嗜中性粒细胞介导的杀菌试验中，针对14型肺炎链球菌的抗血清对III型B组链球菌具有调理作用。III型B组链球菌和14型肺炎链球菌吸附了抗14型肺炎链球菌抗血清的调理活性，从而证明了特异性。090R株B组链球菌（缺乏型抗原）和3型肺炎链球菌并未消除抗14型肺炎链球菌血清的调理活性。使用新生大鼠III型B组链球菌败血症哺乳大鼠模型进行的体内研究表明，针对14型肺炎链球菌的抗血清具有高度保护作用。
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