Han Fengchan, Wang Oumei, Cai Quanxiang
Key Laboratory for Genetic Hearing Disorders in Shandong, Binzhou Medical University, 346 Guanhai Road, Yantai 264003, Shandong, PR China.
Institute of Neurobiology, School of Special Education, Binzhou Medical University, 346 Guanhai Road, Yantai 264003, Shandong, PR China.
J Otol. 2016 Mar;11(1):7-12. doi: 10.1016/j.joto.2016.03.003. Epub 2016 Apr 2.
Age-related hearing loss (AHL), or presbycusis, is the most common neurodegenerative disorder and top communication deficit of the aged population. Genetic predisposition is one of the major factors in the development of AHL. Generally, AHL is associated with an age-dependent loss of sensory hair cells, spiral ganglion neurons and stria vascularis cells in the inner ear. Although the mechanisms leading to genetic hearing loss are not completely understood, caspase-family proteases function as important signals in the inner ear pathology. It is now accepted that mouse models are the best tools to study the mechanism of genetic hearing loss or AHL. Here, we provide a brief review of recent studies on hearing improvement in mouse models of AHL by anti-apoptotic treatment.
年龄相关性听力损失（AHL），即老年性聋，是最常见的神经退行性疾病，也是老年人群最主要的交流障碍。遗传易感性是AHL发生发展的主要因素之一。一般来说，AHL与内耳中感觉毛细胞、螺旋神经节神经元和血管纹细胞随年龄增长而丧失有关。尽管导致遗传性听力损失的机制尚未完全明确，但半胱天冬酶家族蛋白酶在内耳病理过程中起着重要作用。目前人们公认，小鼠模型是研究遗传性听力损失或AHL机制的最佳工具。在此，我们简要综述了近年来通过抗凋亡治疗改善AHL小鼠模型听力的研究。
