Morrill Seth, He David Z Z
Creighton University, 2500 California Plaza, Omaha, NE 68102, USA.
J Otol. 2017 Dec;12(4):151-164. doi: 10.1016/j.joto.2017.08.001. Epub 2017 Aug 10.
Apoptosis, or controlled cell death, is a normal part of cellular lifespan. Cell death of cochlear hair cells causes deafness; an apoptotic process that is not well understood. Worldwide, 1.3 billion humans suffer some form of hearing loss, while 360 million suffer debilitating hearing loss as a direct result of the absence of these cochlear hair cells (Worldwide Hearing, 2014). Much is known about apoptosis in other systems and in other cell types thanks to studies done since the mid-20th century. Here we review current literature on apoptosis in general, and causes of deafness and cochlear hair cells loss as a result of apoptosis. The family of B-cell lymphoma (Bcl) proteins are among the most studied and characterized. We will review current literature on the Bcl2 and Bcl6 protein interactions in relation to apoptosis and their possible roles in vulnerability and survival of cochlear hair cells.
细胞凋亡，即受控细胞死亡，是细胞生命周期的正常组成部分。耳蜗毛细胞的死亡会导致耳聋，这是一个尚未被充分理解的凋亡过程。在全球范围内，有13亿人患有某种形式的听力损失，而3.6亿人因缺乏这些耳蜗毛细胞而直接遭受严重的听力损失（《全球听力报告》，2014年）。自20世纪中叶以来的研究使我们对其他系统和其他细胞类型中的细胞凋亡有了很多了解。在此，我们综述了关于细胞凋亡的现有文献，以及由细胞凋亡导致耳聋和耳蜗毛细胞损失的原因。B细胞淋巴瘤（Bcl）蛋白家族是研究最多、特征最明确的蛋白家族之一。我们将综述关于Bcl2和Bcl6蛋白相互作用与细胞凋亡相关的现有文献，以及它们在耳蜗毛细胞的易损性和存活中的可能作用。
