Gaeta A, Cipriani P, Brenciaglia M I, Rivanera D, Mancini C, Alfani D, Pretagostini R, Molajoni E R, Cortesini R
Microbiologica. 1985 Jul;8(3):225-32.
In the this study the modification of lymphocyte subsets (T3, T4, T8) and Natural Killer (NK) cells in organ transplanted patients treated with Cyclosporin A (CyA) in the course of viral infection, have been analyzed. Different subsets have been studied with the monoclonal antibody method and infective processes have been verified by serological data of seroconversion. Our study has shown that CyA at the adopted doses does not alter NK response to viral infection; in fact, in patients with seroconversion, higher NK values and lower OKT4/OKT8 ratio values have been found with respect to patients who did not show any viral infection serologic data. Furthermore an increased incidence of reject crisis has been observed in patients with seroconversion.
在本研究中，分析了接受环孢素A（CyA）治疗的器官移植患者在病毒感染过程中淋巴细胞亚群（T3、T4、T8）和自然杀伤（NK）细胞的变化。采用单克隆抗体法研究了不同亚群，并通过血清学血清转化数据验证了感染过程。我们的研究表明，所采用剂量的CyA不会改变NK对病毒感染的反应；事实上，在发生血清转化的患者中，相对于未显示任何病毒感染血清学数据的患者，发现NK值更高，OKT4/OKT8比值更低。此外，在发生血清转化的患者中观察到排斥危机的发生率增加。
