Zhang Qing, Yu Ling-Ling, Liu Shi-Qin, Huang Guang-Ying, Xu Sha-Bei, Wang Wei
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Hubei Provincial Collaborative Innovation Center of Preventive Treatment by Acupuncture and Moxibustion/College of Acupuncture-moxibustion and Orthopaedics-traumatology, Hubei University of Traditional Chinese Medicine, Wuhan 430060.
Zhen Ci Yan Jiu. 2018 May 25;43(5):330-4. doi: 10.13702/j.1000-0607.170077.
The objectification of "" of acupuncture is a hot topic in acupuncture research at present, and functional magnetic resonance imaging (fMRI) is one of the most frequently-used techniques for revealing its brain responses. We searched literature about "" from PubMed in recent 10 years by using key words """acupuncture sensation""needling sensation" and fMRI, trying to expound the central mechanism of "" and to put forward our understandings. Acupuncture "" evoked deactivation of the limbic-paralimbic-neocortical network (LPNN)/ default mode network (DMN), including medial prefrontal cortex (frontal pole, anterior cingulate), temporal lobe (amygdala, hippocampus, parahippocampus gyrus, temporal pole), and apparent activation of brain regions as the somatosensory cortex, thalamic-somatosensory area-insular lobe, orbitofrontal cortex, etc., which may enhance the connectivity of brain networks and function in analgesia, anti-anxiety, anti-depression, etc., but the activated and deactivated brain regions are different from study to study possibly due to the stimulated different acupoints, subjects' psychophysical conditions, scanning parameters, image acquiring sequences, etc. It is recommended that the coming stu-dies should pay more attention to the influence of acupuncture "" on brain functions in subjects suffering from diseases, the brain response characteristics of the longer post-effects and the accumulated effects of acupuncture treatment.
针刺“得气”的客观化是目前针刺研究中的热点话题，功能磁共振成像（fMRI）是揭示其脑反应最常用的技术之一。我们使用关键词“针刺感觉”“针感”和fMRI在PubMed上检索了近10年有关“得气”的文献，试图阐述“得气”的中枢机制并提出我们的理解。针刺“得气”诱发边缘-旁边缘-新皮质网络（LPNN）/默认模式网络（DMN）失活，包括内侧前额叶皮质（额极、前扣带回）、颞叶（杏仁核、海马体、海马旁回、颞极），以及体感皮质、丘脑-体感区-岛叶、眶额皮质等脑区明显激活，这可能增强脑网络的连通性并在镇痛、抗焦虑、抗抑郁等方面发挥作用，但不同研究中激活和失活的脑区有所不同，可能是由于刺激的穴位不同、受试者的心理生理状况、扫描参数、图像采集序列等。建议未来的研究应更多关注针刺“得气”对疾病患者脑功能的影响、针刺较长时间后效应及累积效应的脑反应特征。
