Mirnejad Reza, Razeghian-Jahromi Iman, Sepehrimanesh Masood, Zibaeenezhad Mohammad Javad, Lopez-Jornet Pia
Molecular Biology Research Center, Systems Biology and Poisoning Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Curr Protein Pept Sci. 2018;19(11):1124-1130. doi: 10.2174/1389203719666180625111449.
The incidence of cardiovascular disorders, especially coronary artery disease and atherosclerosis, is increasing alarmingly. Clarifying the underlying causes is of the utmost importance and should be elucidated in order to reduce this growing trend. Periodontitis is known as a chronic destructive disease with sophisticated pathophysiological mechanisms that slowly impose negative effects not only on the oral tissues but also on distant organs. Additionally, it has been shown in many studies that atherosclerosis and periodontitis utilized common inflammatory signaling pathways and mediators. Several lines of evidence have demonstrated the signatures of periodontitis-related bacteria in atherosclerotic plaque specimens. It is proposed that virulent proteins of these bacteria probably accelerate the initiation or development of plaque formation on the inner walls of the coronary arteries. Proteomics techniques are very sensitive and have a global point of view. They can help to discover host factors and pathogenrelated biomarkers. This review summarizes the studies focused on the three most important bacterial species involved in both diseases and presents recent findings about the proteomic evaluation of virulence factors of these bacteria. The known mechanisms of action of the virulence factors are also described.
心血管疾病，尤其是冠状动脉疾病和动脉粥样硬化的发病率正以惊人的速度上升。阐明其潜在病因至关重要，必须加以阐明以减少这种不断增长的趋势。牙周炎是一种具有复杂病理生理机制的慢性破坏性疾病，不仅会对口腔组织，还会对远处器官缓慢产生负面影响。此外，许多研究表明，动脉粥样硬化和牙周炎利用共同的炎症信号通路和介质。多条证据已在动脉粥样硬化斑块标本中证实了与牙周炎相关细菌的特征。有人提出，这些细菌的毒性蛋白可能会加速冠状动脉内壁斑块形成的起始或发展。蛋白质组学技术非常灵敏，且具有全局视角。它们有助于发现宿主因素和与病原体相关的生物标志物。本综述总结了聚焦于这两种疾病中涉及的三种最重要细菌物种的研究，并介绍了这些细菌毒力因子蛋白质组学评估的最新发现。还描述了毒力因子已知的作用机制。
