Internal Medicine 'C' Unit, Maggiore Hospital, Local Health Unit of Bologna, Bologna, Italy.
Cambridge Colorectal Unit, Box 201, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, UK.
Future Oncol. 2018 Jul;14(16):1601-1627. doi: 10.2217/fon-2017-0510. Epub 2018 Jun 25.
Malignancies consist not only of cancerous and nonmalignant cells, but also of additional elements, as extracellular matrix. The aim of this review is to summarize meta-analyses, describing breast tissue stiffness and risk of breast carcinoma (BC) assessing the potential relationship between matricellular proteins (MPs) and survival. A systematic computer-based search of published articles, according to PRISMA statement, was conducted through Ovid interface. Mammographic density and tissue stiffness are associated with the risk of BC development, suggesting that MPs may influence BC prognosis. No definitive conclusions are available and additional researches are required to definitively clarify the role of each MP, mammographic density and stiffness in BC development and the mechanisms involved in the onset of this malignancy.
恶性肿瘤不仅包括癌细胞和非恶性细胞，还包括细胞外基质等其他成分。本综述的目的是总结描述乳腺组织硬度和乳腺癌（BC）风险的荟萃分析，评估细胞外基质蛋白（MPs）与生存率之间的潜在关系。根据 PRISMA 声明，通过 Ovid 界面进行了已发表文章的系统计算机检索。乳腺密度和组织硬度与 BC 发展风险相关，表明 MPs 可能影响 BC 的预后。目前尚无明确结论，需要进一步研究以明确每个 MPs、乳腺密度和硬度在 BC 发展中的作用以及这种恶性肿瘤发病机制中涉及的机制。
