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Brain noradrenergic activity in wakefulness and paradoxical sleep: the effect of clonidine.

作者信息

Gaillard J M

出版信息

Neuropsychobiology. 1985;13(1-2):23-5. doi: 10.1159/000118157.

DOI:10.1159/000118157
PMID:2993945
Abstract

Several experiments in which the effects of clonidine (CLN) have been studied in the rat and in man are summarized. CLN inhibits paradoxical sleep (PS) both in the rat and in man. This inhibition is followed by a rebound, but with a different time course in the two species. Wakefulness (W) is enhanced after some critical doses of CLN, and decreased after higher doses. These effects of CLN suggest that alpha 2-adrenoceptors are involved in the regulation of W and PS.

摘要

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