Tao Lihong, Zhang Xinjiang, Duan Zuowei, Wang Yingge, Liu Jiangbing, Hou Hongling, Fang Qi
Department of Neurology, The First Affiliated Hospital of Soochow University, No. 899, Pinghai Road, Suzhou, Jiangsu 215006, China; Department of Neurology, The Affiliated Hospital of Yangzhou University, No. 368, Hanjiang Road, Yangzhou, Jiangsu 225012, China.
Department of Neurology, The Affiliated Hospital of Yangzhou University, No. 368, Hanjiang Road, Yangzhou, Jiangsu 225012, China.
Epilepsy Behav. 2018 Aug;85:150-156. doi: 10.1016/j.yebeh.2018.06.003. Epub 2018 Jun 23.
Women with epilepsy (WWE) are believed to be at risk of sexual dysfunction (SD) and face many sexual challenges because of multiple factors. This study aimed to assess the factors associated with SD in Chinese Han WWE.
This cross-sectional study examined 112 married WWE in the Affiliated Hospital of Yangzhou University with focal (FE) or generalized epilepsy (GE) on antiepileptic drugs (AEDs), and 120 healthy controls without epilepsy, all of Chinese Han nationality. Data collection tools included the Chinese version of Female Sexual Function Index (FSFI), the Chinese version of Zung Self-Rating Anxiety Scale (SAS), the Chinese version of the Zung Self-Rating Depression Scale (SDS), the Chinese version of the revised Morisky Medication Adherence Scale (MMAS-8), and the Chinese version of the National Hospital Seizure Severity Scale (NHS3). Chi-square test, t-test, one-way analysis of variance (ANOVA), and binary logistic regression were used for statistical analysis.
A high rate (70.5%) of SD was detected in WWE, with 24.2% in controls. Sexual dysfunction affected all dimensions: desire (85.7%), arousal (56.3%), lubrication (47.3%), orgasm (66.1%), satisfaction (58.9%), and pain (41.1%). Elevated rates of anxiety (40.2%) and depression (33%) and poor medication adherence (31.3%) were also found in WWE. Binary logistic regression found that poor economic status (odds ratio (OR) = 13.904, 95% confidence interval (CI): 2.025-95.472, P = 0.007 and OR = 6.350, 95% CI: 1.323-30.477, P = 0.021), anxiety (OR = 1.222, 95% CI: 1.055-1.415, P = 0.007), and poor medication adherence (OR = 0.297, 95% CI: 0.124-0.707, P = 0.006) were associated with SD.
The associated factors of SD in Chinese Han WWE are multifactorial. The WWE have higher levels of anxiety, poor family economic status, and poor medication adherence. Medical professionals should not only better control seizures but also evaluate and improve patients' sexual function so as to improve the quality of life of WWE.
癫痫女性（WWE）被认为有性功能障碍（SD）风险，且由于多种因素面临诸多性方面的挑战。本研究旨在评估中国汉族癫痫女性性功能障碍的相关因素。
这项横断面研究纳入了扬州大学附属医院112名已婚癫痫女性，她们患有局灶性癫痫（FE）或全身性癫痫（GE）且正在服用抗癫痫药物（AEDs），以及120名无癫痫的健康对照者，所有研究对象均为中国汉族。数据收集工具包括中文版女性性功能指数（FSFI）、中文版zung自评焦虑量表（SAS）、中文版zung自评抑郁量表（SDS）、中文版修订的莫氏药物依从性量表（MMAS - 8）以及中文版国家医院癫痫严重程度量表（NHS3）。采用卡方检验、t检验、单因素方差分析（ANOVA）和二元逻辑回归进行统计分析。
癫痫女性性功能障碍发生率较高（70.5%），对照组为24.2%。性功能障碍影响所有维度：性欲（85.7%）、性唤起（56.3%）、润滑（47.3%）、性高潮（66.1%）、满意度（58.9%）和疼痛（41.1%）。癫痫女性焦虑（40.2%）和抑郁（33%）发生率升高，药物依从性差（31.3%）。二元逻辑回归发现，经济状况差（比值比（OR）=13.904，95%置信区间（CI）：2.025 - 95.472，P = 0.007且OR = 6.350，95% CI：1.323 - 30.477，P = 0.021）、焦虑（OR = 1.222，95% CI：1.055 - 1.415，P = 0.007）和药物依从性差（OR = 0.297，95% CI：0.124 - 0.707，P = 0.006）与性功能障碍有关。
中国汉族癫痫女性性功能障碍的相关因素是多方面的。癫痫女性焦虑水平较高、家庭经济状况差且药物依从性差。医学专业人员不仅应更好地控制癫痫发作，还应评估并改善患者的性功能，以提高癫痫女性的生活质量。
