Ogunjimi Luqman, Yaria Joseph, Makanjuola Akintomiwa, Ogunniyi Adesola
Department of Internal Medicine, University College Hospital, Ibadan, Nigeria.
Department of Internal Medicine, University College Hospital, Ibadan, Nigeria.
Epilepsy Behav. 2018 Jun;83:108-112. doi: 10.1016/j.yebeh.2018.02.004. Epub 2018 Apr 24.
Sexual dysfunction (SD) has been shown to be more prevalent among females with epilepsy (FWE) when compared with controls. Identified risk factors for SD among FWE include depression, antiepileptic drug (AED) type, epileptic lateralization, and temporal lobe involvement. Despite a huge population of FWE in sub-Saharan Africa and by extension Nigeria, there are limited studies on the effect of AEDs and epilepsy on sexual function among FWE in the region. We therefore studied predictors and patterns of SD among Nigerian FWE.
This was a descriptive study carried out at the University College Hospital, Oyo State - a tertiary hospital in South-Western Nigeria. The Zung Self-rating Depression Scale was used to assess mood. Sexual dysfunction was measured using the Arizona Sexual Experience Scale (ASEX) questionnaire.
The frequency of clinically significant SD among FWE (35, 50.0%) was similar to that of controls (27, 38.6%; p = 0.173). However, the mean ASEX score was higher in FWE than in controls (p = 0.009). Using domains defined by the Diagnostic and Statistical Manual of Mental Disorders - 5th Edition (DSM-V), we observed that FWE had higher scores in all domains. Sexual dysfunction was also more prevalent among FWE with lesional epilepsy when compared with those with nonlesional epilepsy. Standardized beta coefficients from multiple regressions conducted suggest that age of FWE, the presence of motor weakness, and systolic blood pressure contributed to SD.
Females with epilepsy had higher ASEX scores in all domains, with older FWE and those with lesional epilepsy more likely to have SD. Healthcare providers should pay attention to SD among FWE for improved quality of life.
与对照组相比，性功能障碍（SD）在癫痫女性（FWE）中更为普遍。FWE中已确定的SD风险因素包括抑郁、抗癫痫药物（AED）类型、癫痫灶侧别和颞叶受累情况。尽管撒哈拉以南非洲地区，进而尼日利亚有大量的FWE，但关于该地区FWE中AED和癫痫对性功能影响的研究有限。因此，我们研究了尼日利亚FWE中SD的预测因素和模式。
这是一项在奥约州大学学院医院开展的描述性研究，该医院是尼日利亚西南部的一家三级医院。使用zung自评抑郁量表评估情绪。使用亚利桑那性体验量表（ASEX）问卷测量性功能障碍。
FWE中具有临床意义的SD发生率（35例，50.0%）与对照组（27例，38.6%；p=0.173）相似。然而，FWE的ASEX平均得分高于对照组（p=0.009）。使用《精神疾病诊断与统计手册》第5版（DSM-V）定义的领域，我们观察到FWE在所有领域的得分都更高。与非病灶性癫痫的FWE相比，病灶性癫痫的FWE中SD也更为普遍。多元回归得出的标准化β系数表明，FWE的年龄、运动无力的存在和收缩压与SD有关。
癫痫女性在所有领域的ASEX得分都更高，年龄较大的FWE和病灶性癫痫的FWE更有可能出现SD。医疗保健提供者应关注FWE中的SD，以提高生活质量。
