MAIT 细胞在肺部细菌感染中的作用。
Role of MAIT cells in pulmonary bacterial infection.
机构信息
Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, United States.
Department of Pulmonary and Critical Care Medicine, Oregon Health & Sciences University, Portland, OR, 97239, United States; VA Portland Health Care System, Portland, OR, 97239, United States.
出版信息
Mol Immunol. 2018 Sep;101:155-159. doi: 10.1016/j.molimm.2018.06.270. Epub 2018 Jun 26.
Abstract
Mucosal-associated invariant T (MAIT) cells represent a population of innate T cells that is highly abundant in humans. MAIT cells recognize metabolites of the microbial vitamin B pathway that are presented by the major histocompatibility complex (MHC) class I-related protein MR1. Upon bacterial infection, activated MAIT cells produce diverse cytokines and cytotoxic effector molecules and accumulate at the site of infection, thus, MAIT cells have been shown to be protective against various bacterial infections. Here, we summarize the current knowledge of the role of MAIT cells in bacterial pulmonary infection models.
摘要
黏膜相关恒定 T（MAIT）细胞是一类先天 T 细胞，在人类中高度丰富。MAIT 细胞识别微生物维生素 B 途径代谢产物，这些代谢产物由主要组织相容性复合体（MHC）I 类相关蛋白 MR1 呈递。在细菌感染时，活化的 MAIT 细胞产生多种细胞因子和细胞毒性效应分子，并在感染部位聚集，因此，MAIT 细胞被证明可以预防各种细菌感染。在此，我们总结了 MAIT 细胞在细菌性肺部感染模型中的作用的现有知识。
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Am J Respir Cell Mol Biol. 2018 Jun;58(6):767-776. doi: 10.1165/rcmb.2017-0290OC.
2
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