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本文引用的文献

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Riboflavin Metabolism Variation among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of Mucosal-associated Invariant T Cells.肺炎链球菌临床分离株中核黄素代谢的差异导致黏膜相关不变 T 细胞的差异激活。
Am J Respir Cell Mol Biol. 2018 Jun;58(6):767-776. doi: 10.1165/rcmb.2017-0290OC.
2
Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways.多种肺炎链球菌株通过主要组织相容性复合体 I 相关分子依赖性和细胞因子驱动的途径诱导黏膜相关不变 T 细胞反应。
J Infect Dis. 2018 Mar 5;217(6):988-999. doi: 10.1093/infdis/jix647.
3
Functionally diverse human T cells recognize non-microbial antigens presented by MR1.功能多样的人类T细胞识别由MR1呈递的非微生物抗原。
Elife. 2017 May 18;6:e24476. doi: 10.7554/eLife.24476.
4
Drugs and drug-like molecules can modulate the function of mucosal-associated invariant T cells.药物和类药物分子可以调节黏膜相关不变 T 细胞的功能。
Nat Immunol. 2017 Apr;18(4):402-411. doi: 10.1038/ni.3679. Epub 2017 Feb 6.
5
MAIT cells promote inflammatory monocyte differentiation into dendritic cells during pulmonary intracellular infection.黏膜相关恒定T细胞在肺部细胞内感染期间促进炎性单核细胞分化为树突状细胞。
J Exp Med. 2016 Nov 14;213(12):2793-2809. doi: 10.1084/jem.20160637. Epub 2016 Oct 31.
6
MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.MR1 限制性黏膜相关不变 T（MAIT）细胞对非人类灵长类动物的分枝杆菌疫苗接种和感染产生反应。
Mucosal Immunol. 2017 May;10(3):802-813. doi: 10.1038/mi.2016.91. Epub 2016 Oct 19.
7
Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.人 TRAV1-2-阴性 MR1 限制性 T 细胞可检测酿脓链球菌和 MAIT 核糖基类抗原的替代物。
Nat Commun. 2016 Aug 16;7:12506. doi: 10.1038/ncomms12506.
8
Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals.体内感染后黏膜相关恒定T细胞的激活和积累取决于微生物核黄素合成和共刺激信号。
Mucosal Immunol. 2017 Jan;10(1):58-68. doi: 10.1038/mi.2016.39. Epub 2016 May 4.
9
Mucosal-associated invariant T cells in autoimmunity, immune-mediated diseases and airways disease.自身免疫性疾病、免疫介导疾病和气道疾病中的黏膜相关恒定T细胞
Immunology. 2016 May;148(1):1-12. doi: 10.1111/imm.12582. Epub 2016 Feb 9.
10
Mucosal-Associated Invariant T Cells in the Human Gastric Mucosa and Blood: Role in Helicobacter pylori Infection.人胃黏膜和血液中的黏膜相关恒定T细胞：在幽门螺杆菌感染中的作用
Front Immunol. 2015 Sep 17;6:466. doi: 10.3389/fimmu.2015.00466. eCollection 2015.

MAIT 细胞在肺部细菌感染中的作用。

Role of MAIT cells in pulmonary bacterial infection.

机构信息

Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA, 92037, United States.

Department of Pulmonary and Critical Care Medicine, Oregon Health & Sciences University, Portland, OR, 97239, United States; VA Portland Health Care System, Portland, OR, 97239, United States.

出版信息

Mol Immunol. 2018 Sep;101:155-159. doi: 10.1016/j.molimm.2018.06.270. Epub 2018 Jun 26.

DOI:10.1016/j.molimm.2018.06.270
PMID:29940408
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6138534/
Abstract

Mucosal-associated invariant T (MAIT) cells represent a population of innate T cells that is highly abundant in humans. MAIT cells recognize metabolites of the microbial vitamin B pathway that are presented by the major histocompatibility complex (MHC) class I-related protein MR1. Upon bacterial infection, activated MAIT cells produce diverse cytokines and cytotoxic effector molecules and accumulate at the site of infection, thus, MAIT cells have been shown to be protective against various bacterial infections. Here, we summarize the current knowledge of the role of MAIT cells in bacterial pulmonary infection models.

摘要

黏膜相关恒定 T（MAIT）细胞是一类先天 T 细胞，在人类中高度丰富。MAIT 细胞识别微生物维生素 B 途径代谢产物，这些代谢产物由主要组织相容性复合体（MHC）I 类相关蛋白 MR1 呈递。在细菌感染时，活化的 MAIT 细胞产生多种细胞因子和细胞毒性效应分子，并在感染部位聚集，因此，MAIT 细胞被证明可以预防各种细菌感染。在此，我们总结了 MAIT 细胞在细菌性肺部感染模型中的作用的现有知识。