KU Leuven - University of Leuven, Pharmaceutical Analysis, Department of Pharmaceutical and Pharmacological Sciences, O&N2, PB 923, Herestraat 49, Leuven, 3000, Belgium.
Department of Medicinal chemistry, Uppsala University, Husargatan 3, Uppsala, 751 23, Sweden; Kantisto BV, Callenburglaan 22, Baarn, 3742 MV, The Netherlands.
J Pharm Biomed Anal. 2018 Sep 5;158:405-415. doi: 10.1016/j.jpba.2018.06.033. Epub 2018 Jun 20.
This review describes briefly the high rate of counterfeiting of antimicrobial drugs with focus upon its immediate health consequences. The major part of this review encompasses accounts of the improvements achieved in the domain of miniaturization of capillary electrophoresis with capacitively coupled contactless conductivity detection (CE-CD). The application of this principle into the development of portable devices as well as its application to counter the health-system-crippling phenomenon of counterfeit antibiotic formulations, are discussed in the context of developing countries.
本文简要介绍了抗菌药物造假率高的问题，并重点关注其直接的健康后果。本文的主要部分包括毛细管电泳与电容耦合非接触式电导检测（CE-CD）微型化方面的改进。讨论了这一原理在发展中国家应用于便携式设备的开发以及用于对抗破坏卫生系统的假冒抗生素制剂现象的情况。
