Ku Min-Sho
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Division of Allergy, Asthma and Rheumatology, Department of Pediatrics, Chung Shan Medical University Hospital, Taichung, Taiwan.
Neonatology. 2018;114(3):235-241. doi: 10.1159/000489389. Epub 2018 Jun 25.
Preventing the development of allergic skin disease in children is the best way to treat the disease.
Ultraviolet (UV)-free blue light phototherapy has been reported to treat atopic eczema. We evaluated the effect of neonatal phototherapy on allergic skin disease in children.
We randomly recruited 117,041 children from an insurance research database. Those with neonatal jaundice and receiving neonatal phototherapy were classified as the icteric-phototherapy group (n = 4,744), those with neonatal jaundice and not receiving phototherapy were classified as the icteric-non-phototherapy group (n = 5,003), and those without jaundice were classified as the non-icteric group (n = 107,294). We reviewed claims from birth to age 5 years. The prevalence of atopic dermatitis (AD), clinical visit times, and topical prescriptions for allergic skin disease at different ages were compared among groups.
AD prevalence was lower in the icteric-phototherapy group than in the icteric-non-phototherapy group. Moreover, clinical visit times for allergic skin disease were lower at age 1-4 years, and topical agent prescription for allergic skin disease were lower at age 1-5 years, in the icteric-phototherapy group than in the icteric-non-phototherapy group. The decreased use of topical agents could reach 64.29%. The 5-year complications of skin disease and cancer in the phototherapy group were not higher.
To our knowledge, this is the first study to report on the effect of UV-free blue light therapy on allergic skin disease in newborns. Blue light therapy in newborns may be a novel method to efficiently prevent allergic skin disease for at least 5 years.
预防儿童过敏性皮肤病的发生是治疗该疾病的最佳方法。
据报道，无紫外线蓝光光疗可治疗特应性皮炎。我们评估了新生儿光疗对儿童过敏性皮肤病的影响。
我们从一个保险研究数据库中随机招募了117,041名儿童。患有新生儿黄疸并接受新生儿光疗的儿童被分类为黄疸光疗组（n = 4,744），患有新生儿黄疸但未接受光疗的儿童被分类为黄疸非光疗组（n = 5,003），无黄疸的儿童被分类为非黄疸组（n = 107,294）。我们回顾了从出生到5岁的理赔记录。比较了各组间特应性皮炎（AD）的患病率、不同年龄的临床就诊次数以及过敏性皮肤病的局部用药处方情况。
黄疸光疗组的AD患病率低于黄疸非光疗组。此外，黄疸光疗组1 - 4岁时过敏性皮肤病的临床就诊次数以及1 - 5岁时过敏性皮肤病的局部用药处方均低于黄疸非光疗组。局部用药的减少可达64.29%。光疗组5年的皮肤疾病和癌症并发症并不更高。
据我们所知，这是第一项报道无紫外线蓝光疗法对新生儿过敏性皮肤病影响的研究。新生儿蓝光疗法可能是一种有效预防过敏性皮肤病至少5年的新方法。
