Egeberg Alexander, Andersen Yuki M F, Gislason Gunnar, Skov Lone, Thyssen Jacob P
Department of Dermato-Allergology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
Pediatr Allergy Immunol. 2016 Jun;27(4):368-74. doi: 10.1111/pai.12560.
Atopic dermatitis (AD) is a chronic inflammatory skin condition with a multifactorial etiopathogenesis. Studies have suggested that several perinatal factors may influence the risk of AD in early childhood. We investigated possible neonatal risk factors such as jaundice, blue light phototherapy, birthweight, gestational age at birth, and season of birth on the risk of developing AD in the first 5 years of life.
MATERIALS & METHODS: Data were collected through Danish nationwide administrative registers. All newborn children between 1997 and 2007 (n = 673,614) were included in the cohort. Incidence rate ratios (IRRs) were estimated with 95% confidence intervals (95% CIs) by multivariate Poisson regression analyses.
We identified a total of 85,743 children with AD in the first 5 years of life. The risk of AD was slightly increased in children with neonatal jaundice (IRR 1.13 [95% CI 1.06-1.21]). Preterm birth was inversely associated with the risk of AD (IRR 0.74, [95% CI 0.68-0.81]) as well as low birthweight (IRR 0.68, [95% CI 0.61-0.75]). Children born in fall and winter seasons had an increased risk of AD compared to spring and summer. No association between neonatal blue light therapy and the risk of AD was found.
Low birthweight and preterm birth were inversely associated with AD, while neonatal jaundice and cold seasons of birth were associated with an increased risk of AD.
特应性皮炎（AD）是一种具有多因素病因的慢性炎症性皮肤病。研究表明，几种围产期因素可能影响幼儿期患AD的风险。我们调查了可能的新生儿危险因素，如黄疸、蓝光光疗、出生体重、出生时的孕周和出生季节对生命最初5年内患AD风险的影响。
通过丹麦全国性行政登记册收集数据。该队列纳入了1997年至2007年间所有的新生儿（n = 673,614）。通过多变量泊松回归分析估计发病率比（IRR）及其95%置信区间（95%CI）。
我们在生命的前5年中共识别出85,743例患有AD的儿童。新生儿黄疸患儿患AD的风险略有增加（IRR 1.13 [95%CI 1.06 - 1.21]）。早产与AD风险呈负相关（IRR 0.74，[95%CI 0.68 - 0.81]），低出生体重也是如此（IRR 0.68，[95%CI 0.61 - 0.75]）。与春季和夏季出生的儿童相比，秋季和冬季出生的儿童患AD的风险增加。未发现新生儿蓝光治疗与AD风险之间存在关联。
低出生体重和早产与AD呈负相关，而新生儿黄疸和出生在寒冷季节与AD风险增加有关。
