重金属可诱导从骨骼肌分离出的肌浆网囊泡快速释放钙。
Heavy metals induce rapid calcium release from sarcoplasmic reticulum vesicles isolated from skeletal muscle.
作者信息
Abramson J J, Trimm J L, Weden L, Salama G
出版信息
Proc Natl Acad Sci U S A. 1983 Mar;80(6):1526-30. doi: 10.1073/pnas.80.6.1526.
Abstract
Micromolar concentrations of mercury, silver, and other reagents known to react with sulfhydryl groups are shown to stimulate ATPase activity and inhibit active calcium uptake in sarcoplasmic reticulum vesicles derived from rabbit fast skeletal muscle. These effects are caused by a dramatic increase in the calcium permeability of the sarcoplasmic reticulum. Measurements of Ca2+ permeability were made using both isotopes and by spectrophotometric techniques using the Ca2+ indicator arsenazo III. Air oxidation of a sulfhydryl group to a disulfide group also leads to a large increase in the calcium permeability of the sarcoplasmic reticulum.
摘要
已知与巯基发生反应的微摩尔浓度汞、银及其他试剂，可刺激兔快肌骨骼肌肌质网囊泡中的ATP酶活性，并抑制其主动摄取钙。这些效应是由肌质网钙通透性急剧增加所致。利用同位素以及使用钙指示剂偶氮胂III的分光光度技术对Ca2+通透性进行了测量。将一个巯基空气氧化成二硫基团也会导致肌质网的钙通透性大幅增加。
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