Department of Biochemistry and Molecular Biology, University of Salamanca, Lab. 122, Edificio Departamental, Plaza Doctores de la Reina s/n, 37007, Salamanca, Spain.
IBSAL (Instituto de investigación Biomédica de Salamanca), Salamanca, Spain.
J Exp Clin Cancer Res. 2018 Jun 26;37(1):125. doi: 10.1186/s13046-018-0797-0.
Oxidative stress is related to ageing and degenerative diseases, including cancer. However, a moderate amount of reactive oxygen species (ROS) is required for the regulation of cellular signalling and gene expression. A low level of ROS is important for maintaining quiescence and the differentiation potential of haematopoietic stem cells (HSCs), whereas the level of ROS increases during haematopoietic differentiation; thus, suggesting the importance of redox signalling in haematopoiesis. Here, we will analyse the importance of ROS for haematopoiesis and include evidence showing that cells from leukaemia patients live under oxidative stress. The potential sources of ROS will be described. Finally, the level of oxidative stress in leukaemic cells can also be harnessed for therapeutic purposes. In this regard, the reliance of front-line anti-leukaemia chemotherapeutics on increased levels of ROS for their mechanism of action, as well as the active search for novel compounds that modulate the redox state of leukaemic cells, will be analysed.
氧化应激与衰老和退行性疾病有关，包括癌症。然而，细胞信号转导和基因表达的调节需要适量的活性氧 (ROS)。低水平的 ROS 对于维持造血干细胞 (HSCs) 的静止和分化潜能很重要，而在造血分化过程中 ROS 的水平会增加；因此，这表明氧化还原信号在造血中的重要性。在这里，我们将分析 ROS 对造血的重要性，并包括表明白血病患者的细胞在氧化应激下存活的证据。将描述 ROS 的潜在来源。最后，还可以利用白血病细胞中的氧化应激水平进行治疗。在这方面，将分析一线抗白血病化疗药物依赖于增加的 ROS 水平来发挥其作用机制，以及积极寻找调节白血病细胞氧化还原状态的新型化合物。
