人类端粒RNA结构与功能的最新进展
Recent progress in human telomere RNA structure and function.
作者信息
Xu Yan
机构信息
Division of Chemistry, Department of Medical Sciences, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyo-take, Miyazaki 889-1692, Japan.
出版信息
Bioorg Med Chem Lett. 2018 Aug 15;28(15):2577-2584. doi: 10.1016/j.bmcl.2018.06.021. Epub 2018 Jun 14.
PMID:29941190
Abstract
Human telomeric DNA is transcribed into telomeric RNA in cells. Telomeric RNA performs the fundamental biological functions such as regulation and protection of chromosome ends. This digest highlights the human telomere RNA G-quadruplex structures, telomere RNA functions, G-quadruplex-binding small molecules, and future prospects.
摘要
人类端粒DNA在细胞中被转录为端粒RNA。端粒RNA执行诸如调节和保护染色体末端等基本生物学功能。本综述着重介绍了人类端粒RNA G-四链体结构、端粒RNA功能、G-四链体结合小分子以及未来展望。
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