Carreira-Monteiro M E, Jiménez-Vargas J
Rev Esp Fisiol. 1985 Jun;41(2):187-93.
The respiratory effects of naloxone (200 micrograms X kg-1) on dogs, was studied measuring the parameters breath rate, inspiratory volume, breath minute volume, inspiratory time, total time of cycle, inspiratory volume/inspiratory time ratio, and inspiratory time/total time of cycle ratio. The statistical study was made by using the analysis of variance. Naloxone increases all the parameters studied as well as the response to CO2 while it decreases inspiratory time. The results suggest that there are opioid neurons in the respiratory centre. The blockade of the opioid receptors by naloxone almost explains the respiratory effects observed.
研究了纳洛酮（200微克/千克）对犬类的呼吸影响，测量了呼吸频率、吸气量、每分钟呼吸量、吸气时间、周期总时间、吸气量/吸气时间比值以及吸气时间/周期总时间比值等参数。采用方差分析进行统计学研究。纳洛酮增加了所有研究的参数以及对二氧化碳的反应，同时缩短了吸气时间。结果表明呼吸中枢存在阿片样物质神经元。纳洛酮对阿片受体的阻断几乎可以解释所观察到的呼吸效应。
