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血管生成与肝纤维化：中西医结合的治疗之路

Angiogenesis and Hepatic Fibrosis: Western and Chinese Medicine Therapies on the Road.

作者信息

Wang Jing-Si, Zhang Qiu-Yun, Cheng Jin-Lian, Chen Lan-Yu, Yao Nai-Li, Sun Gui-Zhi, Chu Yu-Ling

机构信息

Department of Hepatology, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, 100010, China.

College of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing, 100069, China.

出版信息

Chin J Integr Med. 2018 Sep;24(9):713-720. doi: 10.1007/s11655-018-3007-1. Epub 2018 Jun 25.

DOI:10.1007/s11655-018-3007-1
PMID:29943155
Abstract

Hepatic fibrosis is a common feature of almost all chronic liver diseases. Formation of new vessels (angiogenesis) is a process strictly related to the progressive fibrogenesis which leads to cirrhosis and liver cancer. This review mainly concerns the relationship between angiogenesis and hepatic fibrosis, by considering the mechanism of angiogenesis, cells in angiogenesis, anti-angiogenic and Chinese medicine therapies.

摘要

肝纤维化是几乎所有慢性肝病的共同特征。新血管形成（血管生成）是一个与导致肝硬化和肝癌的进行性纤维化密切相关的过程。本综述主要通过考虑血管生成的机制、血管生成中的细胞、抗血管生成疗法和中医药疗法，探讨血管生成与肝纤维化之间的关系。

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本文引用的文献

1
The Effects of Taoren-Honghua Herb Pair on Pathological Microvessel and Angiogenesis-Associated Signaling Pathway in Mice Model of CCl4-Induced Chronic Liver Disease.桃仁-红花药对对四氯化碳诱导的慢性肝病小鼠模型中病理性微血管及血管生成相关信号通路的影响
Evid Based Complement Alternat Med. 2016;2016:2974256. doi: 10.1155/2016/2974256. Epub 2016 May 11.
2
Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling.更正：布立尼布通过抑制成纤维细胞生长因子（FGF）、血管内皮生长因子（VEGF）和血小板衍生生长因子（PDGF）信号通路，在体内减轻肝纤维化并在体外抑制星状细胞活化。
PLoS One. 2015 Nov 3;10(11):e0142355. doi: 10.1371/journal.pone.0142355. eCollection 2015.
3
Ergosterol Is the Active Compound of Cultured Mycelium Cordyceps sinensis on Antiliver Fibrosis.
麦角甾醇是发酵冬虫夏草菌丝体抗肝纤维化的活性物质。
Evid Based Complement Alternat Med. 2014;2014:537234. doi: 10.1155/2014/537234. Epub 2014 Oct 15.
4
Blocking and reversing hepatic fibrosis in patients with chronic hepatitis B treated by traditional Chinese medicine (tablets of biejia ruangan or RGT): study protocol for a randomized controlled trial.中药（鳖甲软肝片或RGT）治疗慢性乙型肝炎患者肝纤维化的阻断与逆转：一项随机对照试验的研究方案
Trials. 2014 Nov 10;15:438. doi: 10.1186/1745-6215-15-438.
5
Effect of Danshao Huaxian capsule on Gremlin and bone morphogenetic protein-7 expression in hepatic fibrosis in rats.丹芍化纤胶囊对大鼠肝纤维化中Gremlin及骨形态发生蛋白-7表达的影响
World J Gastroenterol. 2014 Oct 28;20(40):14875-83. doi: 10.3748/wjg.v20.i40.14875.
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Update on implications and mechanisms of angiogenesis in liver fibrosis.肝纤维化中血管生成的意义和机制的最新研究进展。
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