The Reproductive Institute of Henan Provincial People's Hospital/Reproductive Hospital of Henan Province, Zhengzhou, China.
Adv Exp Med Biol. 2018;1068:135-148. doi: 10.1007/978-981-13-0502-3_11.
Cancer is a heterogenetic disease at both the level of clinical manifestation and the level of the genome. Single-cell sequencing provides an unprecedented means of characterizing the intra-tumor heterogeneity and detecting and analyzing the genomes of cancer cells. These data will help to reconstruct the understanding of the evolutionary lineage of cancer cells. In the future, single-cell technology is believed to be a useful tool in diagnostic and prognostic application in oncology. The application of single cell technology in clinics will make it possible to detect cancer non-invasively at early stages and to develop precision medicine. In this chapter, we review the research and application status of the single cell technology in cancer.
癌症在临床表现和基因组水平上都是一种异质性疾病。单细胞测序为描述肿瘤内异质性以及检测和分析癌细胞基因组提供了前所未有的手段。这些数据将有助于重建对癌细胞进化谱系的理解。在未来，单细胞技术有望成为肿瘤学诊断和预后应用的有用工具。单细胞技术在临床中的应用将使得在早期阶段非侵入性地检测癌症并开发精准医学成为可能。在本章中，我们综述了单细胞技术在癌症中的研究和应用现状。
