State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China; Department of Radiation Oncology, Cancer Center, First People's Hospital of Foshan Affiliated to Sun Yat-sen University, Foshan 528000, China.
State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China.
Biotechnol Adv. 2017 Jul;35(4):443-449. doi: 10.1016/j.biotechadv.2017.04.001. Epub 2017 Apr 5.
In this review, we have outlined the application of single-cell technology in cancer research. Single-cell technology has made encouraging progress in recent years and now provides the means to detect rare cancer cells such as circulating tumor cells and cancer stem cells. We reveal how this technology has advanced the analysis of intratumor heterogeneity and tumor epigenetics, and guided individualized treatment strategies. The future prospects now are to bring single-cell technology into the clinical arena. We believe that the clinical application of single-cell technology will be beneficial in cancer diagnostics and treatment, and ultimately improve survival in cancer patients.
在这篇综述中，我们概述了单细胞技术在癌症研究中的应用。单细胞技术近年来取得了令人鼓舞的进展，现在为检测循环肿瘤细胞和癌症干细胞等罕见癌细胞提供了手段。我们揭示了这项技术如何推进肿瘤内异质性和肿瘤表观遗传学的分析，并指导个体化治疗策略。现在的未来展望是将单细胞技术引入临床领域。我们相信单细胞技术的临床应用将有益于癌症的诊断和治疗，并最终改善癌症患者的生存率。
