Wang Siqi, Zhang Zhaohuan, Mu Lili, Liu Haiquan, Pan Yingjie, Zhao Yong
College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Shanghai Engineering Research Center of Aquatic-Product Processing & Preservation, Shanghai 201306, China.
Sheng Wu Gong Cheng Xue Bao. 2018 Jun 25;34(6):839-851. doi: 10.13345/j.cjb.180058.
We evaluated the tolerance and pathogenesis of foodborne pathogens with a simulated gastro-intestinal tract model that simulates the chemical, physical and biological effects of human digestion process under laboratory conditions. This could be used to study the tolerance, pathogenesis, gut microbiota interaction and vaccine development of foodborne pathogens, so as to contribute to control and treatment of foodborne pathogens. This review introduces the applications of simulated gastro-intestinal tract model tp evaluate foodborne pathogens, which includes in-vitro static gastro-intestinal model, in-vitro dynamic gastro-intestinal model, conventional animal model and humanized animal model. And the concepts and characteristics of all models are described in detail. Also, the shortcomings of existing models are analyzed, and improvements of artificial gastro-intestinal tract model are prospected. In conclusion, this review could provide comprehensive data for promoting the progress of studying tolerance and pathogenesis of foodborne pathogens.
我们使用一个模拟胃肠道模型评估了食源性病原体的耐受性和致病性，该模型在实验室条件下模拟了人类消化过程的化学、物理和生物学效应。这可用于研究食源性病原体的耐受性、致病性、肠道微生物群相互作用及疫苗开发，从而有助于食源性病原体的控制和治疗。本综述介绍了模拟胃肠道模型在评估食源性病原体方面的应用，包括体外静态胃肠道模型、体外动态胃肠道模型、传统动物模型和人源化动物模型。并详细描述了所有模型的概念和特点。此外，分析了现有模型的缺点，并对人工胃肠道模型的改进进行了展望。总之，本综述可为推动食源性病原体耐受性和致病性研究的进展提供全面的数据。
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